| Autor: |
Feldman ER; Center for Animal Resources and Education, Cornell University, Ithaca, New York;, Email: erf73@cornell.edu., Singh B; Center for Animal Resources and Education, Cornell University, Ithaca, New York., Mishkin NG; Center for Animal Resources and Education, Cornell University, Ithaca, New York; College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado., Lachenauer ER; Cornell University College of Veterinary Medicine, Ithaca, New York., Martin-Flores M; Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, New York., Daugherity EK; Center for Animal Resources and Education, Cornell University, Ithaca, New York. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Association for Laboratory Animal Science : JAALAS [J Am Assoc Lab Anim Sci] 2021 Mar 01; Vol. 60 (2), pp. 221-228. Date of Electronic Publication: 2021 Feb 25. |
| DOI: |
10.30802/AALAS-JAALAS-20-000064 |
| Abstrakt: |
Due to their effective analgesic properties, opioids are worthy of consideration for pain management in rabbits. However, this class of drugs causes undesirable effects including reduced gastrointestinal (GI) motility, reduced fecal output, and delays GI transit times and thus increases the risk of GI stasis. The risk of stasis discourages the use of opioids in rabbits, which could affect animal welfare. Gastroprokinetic agents such as cisapride are effective in promoting gastric emptying in many species, but whether this effect occurs in rabbits is unknown. This study assessed the efficacy of cisapride when administered as a single agent and in combination with buprenorphine in rabbits; efficacy was assessed by measuring GI transit times, fecal output, body weight, and food and water intake. Female New Zealand White rabbits ( n = 10) were studied in a crossover, randomized design and received either vehicle and buprenorphine, cisapride and saline, cisapride and buprenorphine, or vehicle and saline (control) every 8 h for 2 d. Rabbits were anesthetized and administered radio-opaque, barium-filled spheres via orogastric tube. Feces was assessed via radiography for detection of the barium-spheres to determine GI transit time. GI transit time was significantly longer in buprenorphine groups than in control groups, regardless of the use of cisapride. Fecal output and food and water intake were lower for buprenorphine groups than control groups. Cisapride did not significantly alter GI transit, fecal output, or food and water intake. In addition, treatment group did not significantly affect body weight. In conclusion, buprenorphine treatment (0.03 mg/kg TID) prolonged GI transit time and reduced fecal output and food and water consumption in rabbits. Coadministration of buprenorphine and cisapride (0.5 mg/kg) did not ameliorate these effects, and the administration of cisapride at this dose did not appear to affect GI motility in female rabbits. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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