[Adult-onset Still's disease and the neutrophil-lymphocyte index in the Mexican population. A case series report].
| Autor: | Barrientos-Flores CJ; Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Servicio de Medicina Interna, Ciudad de México, México. cora_barflor@hotmail.com., Noyola-García ME, Albarrán-Sánchez A, Torres-Araujo LV, Cano-Ortega Y, Alberti-Minutti P, Anda-Garay JC |
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| Jazyk: | Spanish; Castilian |
| Zdroj: | Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) [Rev Alerg Mex] 2020 Oct-Dec; Vol. 67 (4), pp. 413-420. |
| DOI: | 10.29262/ram.v67i4.811 |
| Abstrakt: | Background: In Mexico, adult-onset Still's disease (AOSD) is one of the causes of fever of unknown origin (FUO). The aim of this study is to describe a series of AOSD cases from a FUO cohort in order to know the clinical and biochemical characteristics of the cases, as well as to describe the neutrophil-lymphocyte index (NLI), which is a clinical marker of inflammation in autoimmune diseases. Case Report: An observational study of 24 cases with AOSD; 72 % of them were women, the median age was 43 years (IQR 37.7-59.7), and the most frequent manifestations were classic rash (84 %) and arthralgia (100 %). All of them had tested negative for rheumatoid factor, antinuclear antibodies, and hyperferritinemia; 83 % had NLI > 3.08. The most used treatment was the combination of methotrexate with corticosteroids; seven patients required biological therapy, and one of them presented a hypersensitivity reaction. Conclusion: When there's FUO, the existence of AOSD should be suspected; also in the presence of rash, arthralgia, hyperferritinemia, and NLI > 3.08. |
| Databáze: | MEDLINE |
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