Signal Intensity Evaluation in the Dentate Nucleus and Subcortical Gray Matter : Effect of Several Administrations of Gadoterate Meglumine in Multiple Sclerosis.

Autor: Hannoun S; Medical Imaging Sciences Program, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon., Kocevar G; CREATIS-CNRS UMR5220 & INSERM U1206, INSA-Lyon, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.; Datascience pole, Seenovate, Lyon, France., Codjia P; Service de Neurologie A, Hôpital Neurologique, Hospices Civils de Lyon, Bron, France., Maucort-Boulch D; Service de Biostatistiques, Hospices Civils de Lyon, Lyon, France., Cotton F; CREATIS-CNRS UMR5220 & INSERM U1206, INSA-Lyon, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.; Service de Radiologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, France., Vukusic S; Service de Neurologie A, Hôpital Neurologique, Hospices Civils de Lyon, Bron, France., Durand-Dubief F; CREATIS-CNRS UMR5220 & INSERM U1206, INSA-Lyon, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.; Service de Neurologie A, Hôpital Neurologique, Hospices Civils de Lyon, Bron, France., Sappey-Marinier D; CREATIS-CNRS UMR5220 & INSERM U1206, INSA-Lyon, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France. dominique.sappey-marinier@univ-lyon1.fr.; CERMEP-Imagerie du Vivant, Université de Lyon, Bron, France. dominique.sappey-marinier@univ-lyon1.fr.
Jazyk: angličtina
Zdroj: Clinical neuroradiology [Clin Neuroradiol] 2022 Sep; Vol. 32 (3), pp. 677-685. Date of Electronic Publication: 2021 Feb 25.
DOI: 10.1007/s00062-021-00995-6
Abstrakt: Purpose: Several studies reported gadolinium deposition in the dentate nuclei (DN) and the globus pallidus (GP) that was associated to linear GBCA administrations rather than macrocyclic. It is therefore imperative to evaluate and assess the safety of cumulative administration of gadoterate meglumine (macrocyclic). Thus, T1-weighted images (T1WI) of multiple sclerosis (MS) patients longitudinally followed for 4 years were retrospectively analyzed.
Methods: In this study 44 patients, 10 with clinically isolated syndrome (CIS), 24 relapsing-remitting MS (RRMS) and 10 primary-progressive MS (PPMS) were examined every 6 months (first four scans) and then with a 1-year interval (last two scans). Image processing consisted in reorienting unenhanced T1WI to standard space, followed by B1 inhomogeneity correction. A patient-specific template was then generated to normalize T1WI signal intensity (SI) and segment the DN and subcortical GM structures. All structures were then transformed to each patient space in order to measure the SI in each region. The cerebellar peduncles (CP) and semi-oval (SO) white matter were then manually delineated and used as reference to calculate SI ratios in the DN and subcortical GM structures. A linear mixed-effect model was finally applied to longitudinally analyze SI variations.
Results: The SI measurements performed in all structures showed no significant increases with the cumulative GBCA administration.
Conclusion: This study showed no significant SI increases within the DN and subcortical GM structures of longitudinally followed MS patients even with the cumulative administration of the macrocyclic GBCA gadoterate meglumine.
(© 2021. Springer-Verlag GmbH, DE part of Springer Nature.)
Databáze: MEDLINE
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