Evaluation of the relationship of lymphangiogenesis markers with disease pathogenesis in patients with Behçet's uveitis.

Autor:	Özgürtaş T; Department of Clinical Biochemistry, Gülhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey., Yücel Ç; Department of Clinical Biochemistry, Gülhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey., Sertoğlu E; Department of Clinical Biochemistry, Gülhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey., Hayran Y; Department of Dermatology, Ankara City Hospital, Ankara, Turkey., Çolak S; Department of Rheumatology, Gülhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey., Tekgöz E; Department of Rheumatology, Gülhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey., Omma A; Department of Rheumatology, Ankara City Hospital, Ankara, Turkey., Durukan AH; Department of Ophthalmology, Gülhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Jazyk:	angličtina
Zdroj:	Acta clinica Belgica [Acta Clin Belg] 2022 Apr; Vol. 77 (2), pp. 387-395. Date of Electronic Publication: 2021 Feb 25.
DOI:	10.1080/17843286.2021.1890451
Abstrakt:	Objectives: The present study aims to evaluate the relationship between Behçet's uveitis and lymphangiogenesis by determining levels of Vascular endothelial growth factor-C (VEGF-C, its receptors sVEGFR-2, sVEGFR-3 and lymphangiogenesis markers podoplanin (PDPN) and lymphatic vessel endothelial hyaluronan receptor 1(LYVE-1), and C-type lectin domain family 1 member B (CLEC2). Materials and Methods: 55 patients with BD uveitis and 31 healthy control subjects were enrolled in the study. Results: sVEGFR-2, sVEGFR-3, VEGF-C/sVEGFR-2 ratio, PDPN and LYVE-1 levels were higher in the patient group. A positive correlation was found between LYVE-1 and hsCRP levels. PDPN had a strong predictive value for progression with a cut-off value of 2 pg/mL, with 69% sensitivity and 68% specificity (p = 0.001). Conclusion: LYVE-1 and PDPN can be good representatives of the ongoing inflammatory processes in BD uveitis and point out that the disease can be related to lymphangiogenesis.
Databáze:	MEDLINE
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