Therapeutic and Prebiotic Effects of Five Different Native Starches on Dextran Sulfate Sodium-Induced Mice Model of Colonic Colitis.

Autor: Xu Z; Shandong Academy of Agricultural Sciences, Institute of Agro-Food Science and Technology, Jinan, 250100, China., Liu W; Shandong Academy of Agricultural Sciences, Institute of Agro-Food Science and Technology, Jinan, 250100, China., Zhang Y; Shandong Academy of Agricultural Sciences, Institute of Agro-Food Science and Technology, Jinan, 250100, China., Zhang D; Qilu Hospital, Shandong University, Jinan, 250012, China., Qiu B; Shandong Academy of Agricultural Sciences, Institute of Agro-Food Science and Technology, Jinan, 250100, China., Wang X; Shandong Academy of Agricultural Sciences, Institute of Agro-Food Science and Technology, Jinan, 250100, China., Liu J; Beijing Technology and Business University (BTBU), Beijing, 10048, China., Liu L; Shandong Academy of Agricultural Sciences, Institute of Agro-Food Science and Technology, Jinan, 250100, China.
Jazyk: angličtina
Zdroj: Molecular nutrition & food research [Mol Nutr Food Res] 2021 Apr; Vol. 65 (8), pp. e2000922. Date of Electronic Publication: 2021 Mar 09.
DOI: 10.1002/mnfr.202000922
Abstrakt: Scope: The availability of studies related to the effects of natural macronutrients on inflammatory bowel disease (IBD) remain relatively limited. This study investigates whether and to what extent the consumption of five different native starches alleviate the clinical symptoms and dysbiosis of gut microbiota associated with colitis.
Methods and Results: Using dextran sodium sulfate (DSS)-induced mouse model of colitis, the potential effects of native potato starch (PS), pea starch (PEAS), corn starch (CS), Chinese yam starch (CYS), and red sorghum starch (RSS) on the clinical manifestations and dysbiosis of gut microbiota are studied. Compared to CS and RSS, the consumption of PEAS, PS, and CYS significantly diminishes clinical enteritis symptoms, including reduced disease activity index, and the alleviated degree of colonic histological damage. Furthermore, the analysis of gut microbiota reveals the significant prebiotic characteristics of PEAS, PS and CYS, as indicated by the maintenance of gut microbiota hemostasis and the inhibition of typically pathogenic bacteria, including Escherichia coli and Helicobacter hepaticus.
Conclusion: Starches from potato, pea, and Chinese yam alleviate colitis symptoms in a mouse model, and also show significant prebiotic characteristics. These findings suggest a cost-effective and convenient dietary strategy for the management of IBD.
(© 2021 Wiley-VCH GmbH.)
Databáze: MEDLINE
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