The effect of ginger ( Zingiber officinale ) feed on cardiac biomarker in medium-dose isoproterenol-induced myocardial toxicity.

Autor: Ojo AO; Department of Physiology, College of Health Sciences, Bowen University, Iwo Nigeria., Ekomaye OH; Department of Physiology, College of Health Sciences, Bowen University, Iwo Nigeria., Owoade OM; Department of Physiology, College of Health Sciences, Bowen University, Iwo Nigeria., Onaseso OO; Department of Physiology, College of Health Sciences, Bowen University, Iwo Nigeria., Adedayo LD; Department of Physiology, College of Health Sciences, Bowen University, Iwo Nigeria., Oluranti OI; Department of Physiology, College of Health Sciences, Bowen University, Iwo Nigeria., Timothy EO; Department of Physiology, College of Health Sciences, Bowen University, Iwo Nigeria., Ayoka A; Department of Physiology, College of Health Sciences, Bowen University, Iwo Nigeria.; Department of Physiological Sciences, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile- Ife.
Jazyk: angličtina
Zdroj: Avicenna journal of phytomedicine [Avicenna J Phytomed] 2021 Jan-Feb; Vol. 11 (1), pp. 1-10.
Abstrakt: Objective: Traditional medicines have been widely used to prevent and treat diseases for thousands of years. This study was designed to evaluate the effect of ginger feed on cardiac biomarker in isoproterenol (ISO)-induced myocardial toxicity.
Materials and Methods: Thirty male Wistar rats were grouped into six groups of five: Control; ISO-induced toxicity; ginger fed; ginger fed before; ginger fed+ ISO simultaneously and ginger fed after. Freshly prepared solution of ISO was injected through intraperitoneal route at a dosage of 20 mg/kg, while the control received distilled water. Blood was collected via cardiac puncture after two weeks of administration, the serum was used to evaluate biomarkers.
Results: The CK-MB and CK of ginger-fed groups were significantly lower compared to ISO group- 8.2±0.5 U/L and 39.36±5.28 U/L respectively, P <0.05. The CK-MB and CK levels of all ginger-fed groups showed no significant difference compared to the control- 2.2±0.3 U/L and 17. 07±3.4.90 U/L, respectively p>0.05, except ginger fed after group where they were significantly higher compared to the control. The mean value of LDH in all ginger-fed groups was lower than the ISO group (67.17±0.88 U/L; p<0.05), but significantly higher (p<0.05) than the control (26.45±2.52 U/L). The mean value of ALT in all ginger fed groups was lower than the ISO group (83.11±4.88U/L; p≤0.05).
Conclusion: Ginger feed hindered toxic effects of isoproterenol.
Databáze: MEDLINE
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