Antioxidant and Anti-Inflammatory Effects of Crocin Ameliorate Doxorubicin-Induced Nephrotoxicity in Rats.

Autor: Hussain MA; Department of Medical Physiology, Faculty of Medicine, Port Said University, Port Said, Egypt., Abogresha NM; Department of Medical Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., AbdelKader G; Department of Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Hassan R; Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Abdelaziz EZ; Department of Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt., Greish SM; Department of Medical Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.; Physiology Department, School of Medicine, Badr University in Egypt (BUC), Egypt.
Jazyk: angličtina
Zdroj: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2021 Feb 15; Vol. 2021, pp. 8841726. Date of Electronic Publication: 2021 Feb 15 (Print Publication: 2021).
DOI: 10.1155/2021/8841726
Abstrakt: Doxorubicin is a drug that belongs to the anthracycline antibiotics. Nephrotoxicity is one of the serious side effects of doxorubicin treatment. Crocin, which is one of the most bioactive components of saffron, has antioxidant, anti-inflammatory, and antitumor effects. The current study was aimed at investigating the possible protective effects of crocin against doxorubicin-induced nephrotoxicity to elucidate the underlying mechanism of this effect. The study included four groups, six rats in each group: normal control, crocin control, doxorubicin, and crocin/doxorubicin. Doxorubicin and crocin/doxorubicin groups received intraperitoneal injections of doxorubicin (3.5 mg/kg twice weekly for 3 weeks). Rats in the crocin control group and the crocin/doxorubicin group were treated with intraperitoneal injections of crocin (100 mg/kg body weight per day) for 3 weeks. Biomarkers of kidney function and oxidative stress as well as the abundance of mRNA for nuclear factor- κβ and inducible nitric oxide synthase were evaluated. In addition, the abundance of cyclooxygenase 2 and tumor necrosis factor α immunoreactivity was evaluated. Crocin treatment had renoprotective effects manifested by significant improvement in kidney function as well as a reduction in the abundance of biomarkers of oxidative stress markers and inflammatory mediators. In conclusion, crocin has a protective effect against doxorubicin-induced nephrotoxicity in rats by serving as an antioxidant and attenuating the expression of NF- κ B, iNOS, COX2, and TNF α .
Competing Interests: All authors declare no related conflicts of interest.
(Copyright © 2021 Mona A. Hussain et al.)
Databáze: MEDLINE
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