DNA Repair Pathways in Cancer Therapy and Resistance.
| Autor: | Li LY; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China.; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China., Guan YD; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China., Chen XS; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China., Yang JM; Department of Cancer Biology and Toxicology, Department of Pharmacology, College of Medicine, Markey Cancer Center, University of Kentucky, Lexington, KY, United States., Cheng Y; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Frontiers in pharmacology [Front Pharmacol] 2021 Feb 08; Vol. 11, pp. 629266. Date of Electronic Publication: 2021 Feb 08 (Print Publication: 2020). |
| DOI: | 10.3389/fphar.2020.629266 |
| Abstrakt: | DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The deregulation of DNA repair pathways is associated with the initiation and progression of cancer. As the primary anti-cancer therapies, ionizing radiation and chemotherapeutic agents induce cell death by directly or indirectly causing DNA damage, dysregulation of the DNA damage response may contribute to hypersensitivity or resistance of cancer cells to genotoxic agents and targeting DNA repair pathway can increase the tumor sensitivity to cancer therapies. Therefore, targeting DNA repair pathways may be a potential therapeutic approach for cancer treatment. A better understanding of the biology and the regulatory mechanisms of DNA repair pathways has the potential to facilitate the development of inhibitors of nuclear and mitochondria DNA repair pathways for enhancing anticancer effect of DNA damage-based therapy. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Li, Guan, Chen, Yang and Cheng.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|