Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging.

Autor: Li H; Department of Surgical Sciences, Section of Otolaryngology, Department of Otolaryngology, Uppsala University Hospital, 751 85, Uppsala, Sweden. hao.li@surgsci.uu.se., Helpard L; School of Biomedical Engineering, Western University, 1152 Richmond St, London, ON, N6A 3K7, Canada., Ekeroot J; Department of Surgical Sciences, Section of Otolaryngology, Department of Otolaryngology, Uppsala University Hospital, 751 85, Uppsala, Sweden., Rohani SA; Department of Otolaryngology, Head and Neck Surgery, Western University, London, ON, Canada., Zhu N; Bio-Medical Imaging and Therapy Facility, Canadian Light Source Inc., University of Saskatchewan, Saskatoon, SK, Canada., Rask-Andersen H; Department of Surgical Sciences, Section of Otolaryngology, Department of Otolaryngology, Uppsala University Hospital, 751 85, Uppsala, Sweden. helge.rask-andersen@surgsci.uu.se., Ladak HM; School of Biomedical Engineering, Western University, 1152 Richmond St, London, ON, N6A 3K7, Canada.; Department of Otolaryngology, Head and Neck Surgery, Western University, London, ON, Canada.; Department of Medical Biophysics, Western University, London, ON, Canada.; Department of Electrical and Computer Engineering, Western University, London, ON, Canada., Agrawal S; School of Biomedical Engineering, Western University, 1152 Richmond St, London, ON, N6A 3K7, Canada.; Department of Otolaryngology, Head and Neck Surgery, Western University, London, ON, Canada.; Department of Medical Biophysics, Western University, London, ON, Canada.; Department of Electrical and Computer Engineering, Western University, London, ON, Canada.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Feb 24; Vol. 11 (1), pp. 4437. Date of Electronic Publication: 2021 Feb 24.
DOI: 10.1038/s41598-021-83225-w
Abstrakt: The human cochlea transforms sound waves into electrical signals in the acoustic nerve fibers with high acuity. This transformation occurs via vibrating anisotropic membranes (basilar and tectorial membranes) and frequency-specific hair cell receptors. Frequency-positions can be mapped within the cochlea to create a tonotopic chart which fits an almost-exponential function with lowest frequencies positioned apically and highest frequencies positioned at the cochlear base (Bekesy 1960, Greenwood 1961). To date, models of frequency positions have been based on a two-dimensional analysis with inaccurate representations of the cochlear hook region. In the present study, the first three-dimensional frequency analysis of the cochlea using dendritic mapping to obtain accurate tonotopic maps of the human basilar membrane/organ of Corti and the spiral ganglion was performed. A novel imaging technique, synchrotron radiation phase-contrast imaging, was used and a spiral ganglion frequency function was estimated by nonlinear least squares fitting a Greenwood-like function (F = A (10 ax  - K)) to the data. The three-dimensional tonotopic data presented herein has large implications for validating electrode position and creating customized frequency maps for cochlear implant recipients.
Databáze: MEDLINE
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