Effects of nifedipine on endothelial function, assessed by flow-mediated vasodilatation in pregnant patients.
| Autor: | Grin L; Department of Obstetrics and Gynecology, Barzilai University Medical Center, Ashkelon, Israel.; Faculty of Health Sciences, Ben-Gurion University of the Negev, Negev, Israel., Laish-Farkash A; Faculty of Health Sciences, Ben-Gurion University of the Negev, Negev, Israel.; Department of Cardiology, Assuta University Medical Center, Ashdod, Israel., Bruoha S; Faculty of Health Sciences, Ben-Gurion University of the Negev, Negev, Israel.; Department of Cardiology, Barzilai University Medical Center, Ashkelon, Israel., Rabinovich M; Department of Obstetrics and Gynecology, Barzilai University Medical Center, Ashkelon, Israel.; Faculty of Health Sciences, Ben-Gurion University of the Negev, Negev, Israel., Harlev A; Department of Obstetrics and Gynecology, Barzilai University Medical Center, Ashkelon, Israel.; Faculty of Health Sciences, Ben-Gurion University of the Negev, Negev, Israel., Anteby E; Department of Obstetrics and Gynecology, Barzilai University Medical Center, Ashkelon, Israel.; Faculty of Health Sciences, Ben-Gurion University of the Negev, Negev, Israel., Yosefy C; Faculty of Health Sciences, Ben-Gurion University of the Negev, Negev, Israel.; Department of Cardiology, Barzilai University Medical Center, Ashkelon, Israel., Shenhav S; Department of Obstetrics and Gynecology, Barzilai University Medical Center, Ashkelon, Israel.; Faculty of Health Sciences, Ben-Gurion University of the Negev, Negev, Israel. |
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| Jazyk: | angličtina |
| Zdroj: | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2022 Dec; Vol. 35 (25), pp. 5498-5503. Date of Electronic Publication: 2021 Feb 24. |
| DOI: | 10.1080/14767058.2021.1885645 |
| Abstrakt: | Objectives: To evaluate the endothelial function, through flow-mediated vasodilation parameters from brachial artery test in women receiving nifedipine for acute tocolysis with threatened preterm delivery. Methods: In a prospective study in a university-affiliated hospital, each participant served as herself control. We evaluated various parameters of endothelial function in 22 patients between 27 and 33 weeks of gestation with a diagnosis of threatened preterm delivery (TPTD) before and after 48 h of nifedipine treatment. Each patient received 80 mg nifedipine per day. The assessment tool was Brachial artery reactivity test (BART). Primary outcome was flow mediated vasodilation (FMD). Results: The average participant's age was 27 ± 4.5 years, median gestational age of 28.5 weeks, BMI, kg/m 2 (mean ± SD) 28.4 ± 3.3. Systolic blood pressure (mmHg) and diastolic blood pressure (mmHg) decreased from 108 ± 6 to 104 ± 5, p < .001 and from 66 ± 4 to 63 ± 4, p < .001, respectively. FMD (%) significantly decrease from 10.8 ± 6.1 to 7.2 ± 4.7, p = .03 prior to and after nifedipine treatment. The basal brachial artery diameter (mm) at rest was (3.19 ± 0.38 versus 3.39 ± 0.49, p = .28) before versus after nifedipine. The largest brachial artery diameter (mm) was (3.54 ± 0.35 versus 3.58 ± 0.44, p = .76) before versus after nifedipine. Conclusions: Our results suggest unfavorable changes in FMD probably as a result of nifedipine used for acute tocolysis. Future prospective studies should try to evaluate the safety of acute and maintenance tocolytic therapy with nifedipine on endothelial function in pregnant women. |
| Databáze: | MEDLINE |
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