Different methods of enhancing the efficacy of topical tacrolimus in extra-facial vitiligo: A comparative study.

Autor: Esmat SM; Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt., Gawdat HI; Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt., Hegazy RA; Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt., Ahmed FS; Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt., Said ER; Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Journal of cosmetic dermatology [J Cosmet Dermatol] 2021 Nov; Vol. 20 (11), pp. 3545-3551. Date of Electronic Publication: 2021 Mar 05.
DOI: 10.1111/jocd.14024
Abstrakt: Background: Vitiligo is an acquired pigmentation disorder due to loss of melanocytes. Topical tacrolimus is effective in vitiligo treatment with minimal effect on extra-facial lesions.
Objective: To assess different methods of enhancing the absorption of topical tacrolimus in extra-facial vitiligo sites using microneedling and occlusion.
Methods: This study included 20 adult patients of both sexes with non-segmental vitiligo. Four extra-facial vitiligo lesions in each patient were randomly labeled A, B, C, and D and treated as follows: area A: tacrolimus ointment (0.03%) application twice/day, area B: microneedling once/week and tacrolimus ointment application directly after microneedling and twice/day the rest of the week, area C: microneedling once/week alone, and area D: tacrolimus ointment application twice/day under occlusion by polyethylene foil. The evaluation was done clinically by calculating the re-pigmentation percent after 6 months of treatment.
Results: Responders in area B were 45%, and 35% in area C, and 25% in both areas A and D. No statistically significant difference was detected regarding the re-pigmentation percent between the four areas (p > 0.05). No correlations were detected between re-pigmentation percent and patients' data.
Conclusion: Combination of microneedling and topical tacrolimus has an edge over monotherapy in vitiligo, and further studies are needed to verify such results.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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