Is There an Association Between Authors' Conflicts of Interest and Outcomes in Clinical Studies Involving Autologous Chondrocyte Implantation?

Autor:	Mayo BC; University of Illinois at Chicago, Chicago, Illinois, USA., Ravella KC; University of Illinois at Chicago, Chicago, Illinois, USA., Onsen L; University of Illinois at Chicago, Chicago, Illinois, USA., Bobko A; University of Illinois at Chicago, Chicago, Illinois, USA., Schwarzman GR; University of Illinois at Chicago, Chicago, Illinois, USA., Steffes MJ; University of Illinois at Chicago, Chicago, Illinois, USA., Miller A; University of Illinois at Chicago, Chicago, Illinois, USA., Hutchinson MR; University of Illinois at Chicago, Chicago, Illinois, USA.
Jazyk:	angličtina
Zdroj:	Orthopaedic journal of sports medicine [Orthop J Sports Med] 2021 Feb 09; Vol. 9 (2), pp. 2325967120979988. Date of Electronic Publication: 2021 Feb 09 (Print Publication: 2021).
DOI:	10.1177/2325967120979988
Abstrakt:	Background: Autologous chondrocyte implantation (ACI) is an increasingly popular technique for the treatment of articular cartilage defects. Because several companies have financial interests in ACI, it is important to consider possible conflicts of interest when evaluating studies reporting outcomes of ACI. Purpose: To determine whether there is an association between authors' financial conflicts of interest and the outcomes of ACI studies. Study Design: Cross-sectional study. Methods: A search of PubMed and MEDLINE databases for "autologous chondrocyte implantation" was performed. Clinical studies published after 2012 through May 15, 2019, and in English were included. Studies were determined to have financial conflicts of interest if any contributing author had relevant conflicts, either self-reported in the published study's disclosures section or reported online in the American Academy of Orthopaedic Surgeons Disclosure database or the Centers for Medicare & Medicaid Services Open Payments database. The outcomes of each study were rated as favorable, equivocal, or unfavorable based on predefined criteria and then tested for association with conflicts of interest through use of the Fisher exact test. Results: A total of 79 studies met the inclusion criteria. Nearly all studies were of level 3 or 4 evidence. Conflicts of interest were established in 51.90% of studies (n = 41). Conflicts that were not self-reported by the authors were discovered in 18% of studies. The level of evidence was not associated with conflict of interest. No statistically significant difference was found in the rate of favorable outcomes between studies with conflicts (92.68%) and those with no conflicts (81.58%) ( P = .126). Publications by US authors were more likely to have financial conflicts of interest ( P = .003). Conclusion: Favorable results were reported in a majority of studies involving ACI. No statistical association was found between the frequency of favorable outcomes and the presence of financial conflicts of interest, country of authorship, or level of evidence. There was a trend toward more favorable outcomes in studies with conflicts of interest. Additionally, nearly 20% of publications had possible conflicts found online that were not self-reported. It is critical for orthopaedic surgeons to judiciously evaluate published studies and consider financial conflicts of interest before performing ACI techniques on patients. Competing Interests: The authors declared that there are no conflicts of interest in the authorship and publication of this contribution. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto. (© The Author(s) 2021.)
Databáze:	MEDLINE
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