Occupational socioeconomic risk associations for head and neck cancer in Europe and South America: individual participant data analysis of pooled case-control studies within the INHANCE Consortium.

Autor:	Conway DI; School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK David.Conway@glasgow.ac.uk., Hovanec J; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Ruhr University Bochum, Bochum, Nordrhein-Westfalen, Germany., Ahrens W; Leibniz Institute for Prevention Research and Epidemiology, Bremen, Germany., Ross A; School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK., Holcatova I; Institute of Hygiene and Epidemiology, Charles University First Faculty of Medicine, Praha, Czech Republic., Lagiou P; School of Medicine, National and Kapodistrian University of Athens, Athens, Attica, Greece., Serraino D; Oncology Reference Center, Aviano, Friuli-Venezia Giulia, Italy., Canova C; Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padova, Veneto, Italy., Richiardi L; Department of Medical Sciences, University of Turin, Torino, Piemonte, Italy., Healy C; School of Dental Science, Trinity College Dublin, Dublin, Ireland., Kjaerheim K; Cancer Registry of Norway, Oslo, Norway., Macfarlane GJ; Epidemiology Group, University of Aberdeen, Aberdeen, UK., Thomson P; Faculty of Dentistry, University of Hong Kong, Hong Kong, Hong Kong., Agudo A; Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Hospitalet de Llobregat, Catalunya, Spain., Znaor A; International Agency for Research on Cancer, Lyon, Rhône-Alpes, France., Brennan P; International Agency for Research on Cancer, Lyon, Rhône-Alpes, France., Luce D; University of Rennes 1-Health Sciences Campus Villejean, Rennes, Bretagne, France.; Institute for Research in Health, Environment and Work, National Institute of Health and Medical Research, Rennes, Bretagne, France.; School of Advanced Studies in Public Health, Rennes, Bretagne, France., Menvielle G; Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France., Stucker I; Paris-Sud University, Saint-Aubin, Île-de-France, France.; Environmental Epidemiology of Cancer, Centre for Research in Epidemiology and Population Health, National Institute of Health and Medical Research, Villejuif, Île-de-France, France., Benhamou S; Gustave-Roussy Institute, Villejuif, Île-de-France, France., Ramroth H; Institute of Public Health, University of Heidelberg, Heidelberg, Baden-Württemberg, Germany., Boffetta P; The Tisch Cancer Institute and Institute for Translational Epidemiology, Mount Sinai School of Medicine, New York, New York, USA.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Emilia-Romagna, Italy., Vilensky M; Institute of Oncology Angel H Roffo, University of Buenos Aires, Buenos Aires, Argentina., Fernandez L; National Institute of Oncology and Radiobiology, La Habana, Cuba., Curado MP; Epidemiology, AC Camargo Cancer Center International Research Center, Sao Paulo, Brazil., Menezes A; Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil., Daudt A; Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil., Koifman R; Fundacao Oswaldo Cruz, National School of Public Health, Rio de Janeiro, Brazil., Wunsch-Filho V; University of Sao Paulo, Sao Paulo, Brazil., Yuan-Chin AL; Division of Public Health, Department of Family and Preventive Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA., Hashibe M; Division of Public Health, Department of Family and Preventive Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA., Behrens T; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Ruhr University Bochum, Bochum, Nordrhein-Westfalen, Germany., McMahon AD; School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK.
Jazyk:	angličtina
Zdroj:	Journal of epidemiology and community health [J Epidemiol Community Health] 2021 Aug; Vol. 75 (8), pp. 779-787. Date of Electronic Publication: 2021 Feb 23.
DOI:	10.1136/jech-2020-214913
Abstrakt:	Background: The association between socioeconomic disadvantage (low education and/or income) and head and neck cancer is well established, with smoking and alcohol consumption explaining up to three-quarters of the risk. We aimed to investigate the nature of and explanations for head and neck cancer risk associated with occupational socioeconomic prestige (a perceptual measure of psychosocial status), occupational socioeconomic position and manual-work experience, and to assess the potential explanatory role of occupational exposures. Methods: Pooled analysis included 5818 patients with head and neck cancer (and 7326 control participants) from five studies in Europe and South America. Lifetime job histories were coded to: (1) occupational social prestige-Treiman's Standard International Occupational Prestige Scale (SIOPS); (2) occupational socioeconomic position-International Socio-Economic Index (ISEI); and (3) manual/non-manual jobs. Results: For the longest held job, adjusting for smoking, alcohol and nature of occupation, increased head and neck cancer risk estimates were observed for low SIOPS OR=1.88 (95% CI: 1.64 to 2.17), low ISEI OR=1.74 (95% CI: 1.51 to 1.99) and manual occupations OR=1.49 (95% CI: 1.35 to 1.64). Following mutual adjustment by socioeconomic exposures, risk associated with low SIOPS remained OR=1.59 (95% CI: 1.30 to 1.94). Conclusions: These findings indicate that low occupational socioeconomic prestige, position and manual work are associated with head and neck cancer, and such risks are only partly explained by smoking, alcohol and occupational exposures. Perceptual occupational psychosocial status (SIOPS) appears to be the strongest socioeconomic factor, relative to socioeconomic position and manual/non-manual work. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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