| Autor: |
Jevnikar AM; Department of Medicine, Victoria Hospital, London, Ont., Canada., Finnie KJ, Dennis B, Plummer DT, Avila A, Linton AL |
| Jazyk: |
angličtina |
| Zdroj: |
Nephron [Nephron] 1988; Vol. 48 (4), pp. 300-5. |
| DOI: |
10.1159/000184947 |
| Abstrakt: |
Nephrotoxicity of radio-opaque contrast media (CM) is generally believed to involve toxic injury of proximal tubular cells. Measurement of urinary tubular enzyme excretion has been advocated as a sensitive marker of such toxic injury. It has been claimed that the new low-osmolality or nonionic CM reduce the incidence of nephrotoxicity but this remains uncertain. We studied 23 patients with normal renal function undergoing coronary angiography; patients were randomized into three groups receiving either diatrizoate (1,800 mmol/kg H2O), ioxaglate (600 mmol/kg H2O) or iohexol (850 mmol/kg H2O). Urinary excretion of a panel of enzymes increased significantly in all groups by 20 h (p less than 0.05 to less than 0.005). Alanine aminopeptidase excretion at 20 h was greater after the administration of high osmolality ionic CM than with the others but all three CM produced a similar pattern of enzyme excretion. No significant change in glomerular filtration rate was found in any group so the significance of the enzymuria remains uncertain. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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