Annexins: Involvement in cholesterol homeostasis, inflammatory response and atherosclerosis.

Autor: Méndez-Barbero N; Laboratorio de Patología Vascular, IIS-Fundación Jiménez Díaz, Madrid, España; CIBER de Enfermedades Cardiovasculares (CIBERCV), España., Gutiérrez-Muñoz C; Laboratorio de Patología Vascular, IIS-Fundación Jiménez Díaz, Madrid, España; CIBER de Enfermedades Cardiovasculares (CIBERCV), España., Blázquez-Serra R; CIBER de Enfermedades Cardiovasculares (CIBERCV), España., Martín-Ventura JL; Laboratorio de Patología Vascular, IIS-Fundación Jiménez Díaz, Madrid, España; CIBER de Enfermedades Cardiovasculares (CIBERCV), España., Blanco-Colio LM; Laboratorio de Patología Vascular, IIS-Fundación Jiménez Díaz, Madrid, España; CIBER de Enfermedades Cardiovasculares (CIBERCV), España. Electronic address: lblanco@fjd.es.
Jazyk: English; Spanish; Castilian
Zdroj: Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis [Clin Investig Arterioscler] 2021 Jul-Aug; Vol. 33 (4), pp. 206-216. Date of Electronic Publication: 2021 Feb 20.
DOI: 10.1016/j.arteri.2020.12.010
Abstrakt: The annexin superfamily consists of 12 proteins with a highly structural homology that binds to phospholipids depending on the availability of Ca 2+ -dependent. Different studies of overexpression, inhibition, or using recombinant proteins have linked the main function of these proteins to their dynamic and reversible binding to membranes. Annexins are found in multiple cellular compartments, regulating different functions, such as membrane trafficking, anchoring to the cell cytoskeleton, ion channel regulation, as well as pro- or anti-inflammatory and anticoagulant activities. The use of animals deficient in any of these annexins has established their possible functions in vivo, demonstrating that annexins can participate in relevant functions independent of Ca 2+ signalling. This review will focus mainly on the role of different annexins in the pathological vascular remodelling that underlies the formation of the atherosclerotic lesion, as well as in the control of cholesterol homeostasis.
(Copyright © 2021 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE