The Central Aspects of Pain in the Knee (CAP-Knee) questionnaire; a mixed-methods study of a self-report instrument for assessing central mechanisms in people with knee pain.

Autor: Akin-Akinyosoye K; Pain Centre Versus Arthritis, University of Nottingham, UK; Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, UK. Electronic address: kehinde.akin@nottingham.ac.uk., James RJE; Pain Centre Versus Arthritis, University of Nottingham, UK; School of Psychology, University of Nottingham, UK. Electronic address: richard.james4@nottingham.ac.uk., McWilliams DF; Pain Centre Versus Arthritis, University of Nottingham, UK; Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, UK. Electronic address: dan.mcwilliams@nottingham.ac.uk., Millar B; Pain Centre Versus Arthritis, University of Nottingham, UK; Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, UK. Electronic address: bonnie.millar@nottingham.ac.uk., das Nair R; Pain Centre Versus Arthritis, University of Nottingham, UK; Institute of Mental Health, University of Nottingham, UK; Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, UK. Electronic address: Roshan.dasnair@nottingham.ac.uk., Ferguson E; Pain Centre Versus Arthritis, University of Nottingham, UK; School of Psychology, University of Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, UK. Electronic address: Eamonn.Ferguson@nottingham.ac.uk., Walsh DA; Pain Centre Versus Arthritis, University of Nottingham, UK; Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, UK; Rheumatology, Sherwood Forest Hospitals NHS Foundation Trust, Sutton-in-Ashfield, Nottinghamshire, UK. Electronic address: david.walsh@nottingham.ac.uk.
Jazyk: angličtina
Zdroj: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2021 Jun; Vol. 29 (6), pp. 802-814. Date of Electronic Publication: 2021 Feb 20.
DOI: 10.1016/j.joca.2021.02.562
Abstrakt: Objectives: Pain is the prevailing symptom of knee osteoarthritis. Central sensitisation creates discordance between pain and joint pathology. We previously reported a Central Pain Mechanisms trait derived from eight discrete characteristics: Neuropathic-like pain, Fatigue, Cognitive-impact, Catastrophising, Anxiety, Sleep disturbance, Depression, and Pain distribution. We here validate and show that an 8-item questionnaire, Central Aspects of Pain in the Knee (CAP-Knee) is associated both with sensory- and affective- components of knee pain severity.
Methods: Participants with knee pain were recruited from the Investigating Musculoskeletal Health and Wellbeing study in the East Midlands, UK. CAP-Knee items were refined following cognitive interviews. Psychometric properties were assessed in 250 participants using Rasch-, and factor-analysis, and Cronbach's alpha. Intra-class correlation coefficients tested repeatability. Associations between CAP-Knee and McGill Pain questionnaire pain severity scores were assessed using linear regression.
Results: CAP-Knee targeted the knee pain sample well. Cognitive interviews indicated that participants interpreted CAP-Knee items in diverse ways, which aligned to their intended meanings. Fit to the Rasch model was optimised by rescoring each item, producing a summated score from 0 to 16. Internal consistency was acceptable (Cronbach's alpha = 0.74) and test-retest reliability was excellent (ICC 2,1  = 0.91). Each CAP-Knee item contributed uniquely to one discrete 'Central Mechanisms trait' factor. High CAP-Knee scores associated with worse overall knee pain intensity, and with each of sensory- and affective- McGill Pain Questionnaire scores.
Conclusion: CAP-Knee is a simple and valid self-report questionnaire, which measures a single 'Central Mechanisms' trait, and may help identify and target centrally-acting treatments aiming to reduce the burden of knee pain.
Competing Interests: Declaration of competing interest Kehinde Akin-Akinyosoye: None declared. Richard J.E. James: None declared. Bonnie Millar: None declared. Daniel F. McWilliams: None declared. Roshan das Nair: None declared. Eamonn Ferguson: None declared. David A. Walsh: None declared.
(Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE