Polyoxygenated sesquiterpenoids from Salvia castanea and their potential anti-Alzheime's disease bioactivities.

Autor: Su PJ; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China., Zhang ZP; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China., Cui WB; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China., Liu X; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China., Wang RY; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China., Zhi DJ; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China., Qi FM; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China., Chen XH; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China., Li YQ; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China., Djimabi K; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China., Guo YQ; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China., Zhang ZX; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address: zhangzhx@lzu.edu.cn., Fei DQ; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, People's Republic of China. Electronic address: feidq@lzu.edu.cn.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2021 Jun; Vol. 151, pp. 104867. Date of Electronic Publication: 2021 Feb 20.
DOI: 10.1016/j.fitote.2021.104867
Abstrakt: Salvia castanea (Family Labiatae), a perennial fragrant herb with castaneous flowers, is mainly distributed in areas with an altitude of 2500-3750 m. The roots of this plant were used as a tea drink by local residents to strengthen physical health. The aim of present study was to acquire secondary metabolites of the ethanol extract obtained from the whole plant of S. castanea and to evaluate their potential anti-Alzheimer's disease. Six new sesquiterpene lactones, salcastanins A-F (1-6), together with three known guaiane-type sesquiterpenoids nubiol (7), nubdienolide (8), and nubenolide (9), were separated from the whole plant of S. castanea. The structures of these compounds were determined by HRESIMS and NMR experiments. The absolute configurations of 1-6 were ascertained by electronic circular dichroism (ECD) experiments. The humanized Caenorhabditis elegans AD pathological model was used to evaluate anti-Alzheimer's disease (AD) activities of 1-9. The results showed the compounds 1-3 and 7 significantly delayed AD-like symptoms of worm paralysis phenotype, which could be used as novel anti-AD candidates.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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