Impact of Smoking, Obesity and Maternal Diabetes on SHBG Levels in Newborns.

Autor:	Aydin BK; Division of Pediatric Endocrinology, Metabolism and Diabetes, Istanbul University, Istanbul, Turkey., Yasa B; Division of Neonatology, Istanbul University, Istanbul, Turkey., Moore JP; Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, Kentucky, USA., Yasa C; Department of Obstetrics, Gynecology and Women's Health, Istanbul University, Istanbul, Turkey., Poyrazoglu S; Division of Pediatric Endocrinology, Metabolism and Diabetes, Istanbul University, Istanbul, Turkey., Bas F; Division of Pediatric Endocrinology, Metabolism and Diabetes, Istanbul University, Istanbul, Turkey., Coban A; Division of Neonatology, Istanbul University, Istanbul, Turkey., Darendeliler F; Division of Pediatric Endocrinology, Metabolism and Diabetes, Istanbul University, Istanbul, Turkey., Winters SJ; Division of Endocrinology, Metabolism and Diabetes. University of Louisville, Louisville, Kentucky, USA.
Jazyk:	angličtina
Zdroj:	Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association [Exp Clin Endocrinol Diabetes] 2022 May; Vol. 130 (5), pp. 335-342. Date of Electronic Publication: 2021 Feb 22.
DOI:	10.1055/a-1375-4176
Abstrakt:	Background: Low levels of SHBG have become a marker for insulin resistance and diabetes. Babies born to mothers who are obese, have diabetes, or smoke during pregnancy are at greater risk of developing obesity and diabetes later in life. Aims: To examine the impact of maternal obesity, diabetes and smoking on SHBG levels in newborns. Study Design: This cross-sectional study is part of an ongoing multicenter, longitudinal study. Subjects: 98 healthy newborns and their parents, including 16 mothers with diabetes and 31 mothers with a smoking history. Outcome Measures: Cord blood and second day venipuncture samples were collected for measurement of SHBG and insulin. Results: Babies born to mothers with diabetes had lower SHBG levels in cord blood [14.0 (8.9-20.4) vs. 19.6 (14.9-25.1) nmol/L; p=0.011] and on day 2 [18.8 (12.6-21.2) vs. 22.9 (17.1-29.1) nmol/L; p=0.015] than controls. Maternal diabetes remained negatively associated with SHBG levels in cord blood (p=0.02) and on day 2 (p=0.04) when adjusted for mothers' age, smoking status, pre-pregnancy weight and weight gain during pregnancy. SHBG levels in cord blood and day 2 samples were similar in babies born to mothers who were overweight-obese but not diabetic vs. normal weight, or were smokers when compared to non-smokers. Conclusions: SHBG levels are lower in newborns born to mothers with diabetes than without diabetes, and may be a marker for babies' life-long risk for abnormal metabolic health. On the other hand, the adverse effects of tobacco smoke on the fetus do not appear to directly influence SHBG levels. Competing Interests: The authors declare that they have no conflict of interest. (Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany.)
Databáze:	MEDLINE
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