Genomic insights into the formation of human populations in East Asia.

Autor: Wang CC; Department of Anthropology and Ethnology, Institute of Anthropology, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China. wang@xmu.edu.cn.; Department of Genetics, Harvard Medical School, Boston, MA, USA. wang@xmu.edu.cn.; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany. wang@xmu.edu.cn.; MOE Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China. wang@xmu.edu.cn., Yeh HY; School of Humanities, Nanyang Technological University, Nanyang, Singapore., Popov AN; Scientific Museum, Far Eastern Federal University, Vladivostok, Russia., Zhang HQ; Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China., Matsumura H; School of Health Science, Sapporo Medical University, Sapporo, Japan., Sirak K; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA., Cheronet O; Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria., Kovalev A; Institute of Archaeology, Russian Academy of Sciences, Moscow, Russia., Rohland N; Department of Genetics, Harvard Medical School, Boston, MA, USA., Kim AM; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Anthropology, Harvard University, Cambridge, MA, USA., Mallick S; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Bernardos R; Department of Genetics, Harvard Medical School, Boston, MA, USA., Tumen D; Department of Anthropology and Archaeology, National University of Mongolia, Ulaanbaatar, Mongolia., Zhao J; Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China., Liu YC; Institute of Archaeology, National Cheng Kung University, Tainan, Taiwan., Liu JY; Department of Anthropology, University of Washington, Seattle, WA, USA., Mah M; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Wang K; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany., Zhang Z; Department of Genetics, Harvard Medical School, Boston, MA, USA., Adamski N; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Broomandkhoshbacht N; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Callan K; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Candilio F; Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria., Carlson KSD; Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria., Culleton BJ; Institutes of Energy and the Environment, The Pennsylvania State University, University Park, PA, USA., Eccles L; Department of Anthropology, Pennsylvania State University, University Park, PA, USA., Freilich S; Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria., Keating D; Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria., Lawson AM; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Mandl K; Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria., Michel M; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Oppenheimer J; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Özdoğan KT; Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria., Stewardson K; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Wen S; Institute of Archaeological Science, Fudan University, Shanghai, China., Yan S; School of Ethnology and Sociology, Minzu University of China, Beijing, China., Zalzala F; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Chuang R; Institute of Archaeology, National Cheng Kung University, Tainan, Taiwan., Huang CJ; Institute of Archaeology, National Cheng Kung University, Tainan, Taiwan., Looh H; Institute of History and Philology, Institute of History and Philology, Academia Sinica, Taipei, Taiwan., Shiung CC; Institute of Archaeology, National Cheng Kung University, Tainan, Taiwan., Nikitin YG; Museum of Archaeology and Ethnology, Institute of History, Archaeology and Ethnology, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia., Tabarev AV; Institute of Archaeology and Ethnography, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia., Tishkin AA; Department of Archeology, Ethnography and Museology, Altai State University, Barnaul, Russia., Lin S; Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China., Sun ZY; Shaanxi Provincial Institute of Archaeology, Xi'an, China., Wu XM; Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China., Yang TL; Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China., Hu X; Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China., Chen L; School of Cultural Heritage, Northwest University, Xi'an, China., Du H; Xi'an AMS Center, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an, China., Bayarsaikhan J; Research Center at the National Museum of Mongolia, Ulaanbaatar, Mongolia., Mijiddorj E; Department of Archaeology, Ulaanbaatar State University, Ulaanbaatar, Mongolia., Erdenebaatar D; Department of Archaeology, Ulaanbaatar State University, Ulaanbaatar, Mongolia., Iderkhangai TO; Department of Archaeology, Ulaanbaatar State University, Ulaanbaatar, Mongolia., Myagmar E; Department of Anthropology and Archaeology, National University of Mongolia, Ulaanbaatar, Mongolia., Kanzawa-Kiriyama H; Department of Anthropology, National Museum of Nature and Science, Tsukuba, Japan., Nishino M; Archaeological Center of Chiba City, Chiba, Japan., Shinoda KI; Department of Anthropology, National Museum of Nature and Science, Tsukuba, Japan., Shubina OA; Department of Archeology, Sakhalin Regional Museum, Yuzhno-Sakhalinsk, Russia., Guo J; Department of Anthropology and Ethnology, Institute of Anthropology, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China., Cai W; Department of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, China., Deng Q; Department of Human Anatomy and Center for Genomics and Personalized Medicine, Guangxi Medical University, Nanning, China., Kang L; Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, Ministry of Education, School of Medicine, Xizang Minzu University (Tibet University for Nationalities), Xianyang, China., Li D; Institute for History and Culture of Science & Technology, Guangxi University for Nationalities, Nanning, China., Li D; Department of Biology, Hainan Medical University, Haikou, China., Lin R; Department of Biology, Hainan Medical University, Haikou, China., Nini; Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, Ministry of Education, School of Medicine, Xizang Minzu University (Tibet University for Nationalities), Xianyang, China., Shrestha R; MOE Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China., Wang LX; MOE Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China., Wei L; Department of Anthropology and Ethnology, Institute of Anthropology, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China., Xie G; College of History, Culture and Tourism, Guangxi Normal University, Guilin, China.; Guangxi Institute of Cultural Relics Protection and Archaeology, Nanning, China., Yao H; Belt and Road Research Center for Forensic Molecular Anthropology, Key Laboratory of Evidence Science of Gansu Province, Gansu Institute of Political Science and Law, Lanzhou, China., Zhang M; MOE Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China., He G; Department of Anthropology and Ethnology, Institute of Anthropology, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China., Yang X; Department of Anthropology and Ethnology, Institute of Anthropology, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China., Hu R; Department of Anthropology and Ethnology, Institute of Anthropology, State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China., Robbeets M; Eurasia3angle Research group, Max Planck Institute for the Science of Human History, Jena, Germany., Schiffels S; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany., Kennett DJ; Department of Anthropology, University of California Santa Barbara, Santa Barbara, CA, USA., Jin L; MOE Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China., Li H; MOE Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China., Krause J; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany. krause@shh.mpg.de., Pinhasi R; Department of Evolutionary Anthropology, University of Vienna, Vienna, Austria. ron.pinhasi@univie.ac.at., Reich D; Department of Genetics, Harvard Medical School, Boston, MA, USA. reich@genetics.med.harvard.edu.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA. reich@genetics.med.harvard.edu.; Broad Institute of Harvard and MIT, Cambridge, MA, USA. reich@genetics.med.harvard.edu.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA. reich@genetics.med.harvard.edu.
Jazyk: angličtina
Zdroj: Nature [Nature] 2021 Mar; Vol. 591 (7850), pp. 413-419. Date of Electronic Publication: 2021 Feb 22.
DOI: 10.1038/s41586-021-03336-2
Abstrakt: The deep population history of East Asia remains poorly understood owing to a lack of ancient DNA data and sparse sampling of present-day people 1,2 . Here we report genome-wide data from 166 East Asian individuals dating to between 6000 BC and AD 1000 and 46 present-day groups. Hunter-gatherers from Japan, the Amur River Basin, and people of Neolithic and Iron Age Taiwan and the Tibetan Plateau are linked by a deeply splitting lineage that probably reflects a coastal migration during the Late Pleistocene epoch. We also follow expansions during the subsequent Holocene epoch from four regions. First, hunter-gatherers from Mongolia and the Amur River Basin have ancestry shared by individuals who speak Mongolic and Tungusic languages, but do not carry ancestry characteristic of farmers from the West Liao River region (around 3000 BC), which contradicts theories that the expansion of these farmers spread the Mongolic and Tungusic proto-languages. Second, farmers from the Yellow River Basin (around 3000 BC) probably spread Sino-Tibetan languages, as their ancestry dispersed both to Tibet-where it forms approximately 84% of the gene pool in some groups-and to the Central Plain, where it has contributed around 59-84% to modern Han Chinese groups. Third, people from Taiwan from around 1300 BC to AD 800 derived approximately 75% of their ancestry from a lineage that is widespread in modern individuals who speak Austronesian, Tai-Kadai and Austroasiatic languages, and that we hypothesize derives from farmers of the Yangtze River Valley. Ancient people from Taiwan also derived about 25% of their ancestry from a northern lineage that is related to, but different from, farmers of the Yellow River Basin, which suggests an additional north-to-south expansion. Fourth, ancestry from Yamnaya Steppe pastoralists arrived in western Mongolia after around 3000 BC but was displaced by previously established lineages even while it persisted in western China, as would be expected if this ancestry was associated with the spread of proto-Tocharian Indo-European languages. Two later gene flows affected western Mongolia: migrants after around 2000 BC with Yamnaya and European farmer ancestry, and episodic influences of later groups with ancestry from Turan.
Databáze: MEDLINE