Epidemiology of cutaneous involvement in Sjögren syndrome: Data from three French pSS populations (TEARS, ASSESS, diapSS).

Autor: Villon C; Dermatologie, CHU de Brest, 29200 Brest, France., Orgeolet L; Dermatologie, CHU de Brest, 29200 Brest, France., Roguedas AM; Dermatologie, CHU de Brest, 29200 Brest, France., Misery L; Dermatologie, CHU de Brest, 29200 Brest, France., Gottenberg JE; Rhumatologie, CHU de Strasbourg, hôpitaux universitaires Strasbourg, 67000 Strasbourg, France., Cornec D; Inserm 1227, LabEx IGO, rhumatologie, centre de référence maladies rares CERAINO, université de Bretagne Occidentale, CHU de Brest, 29200 Brest, France., Jousse-Joulin S; Inserm 1227, LabEx IGO, rhumatologie, centre de référence maladies rares CERAINO, université de Bretagne Occidentale, CHU de Brest, 29200 Brest, France., Seror R; Rhumatologie, université Paris Sud XI, AP-HP, 94270 Le Kremlin-Bicêtre, France., Berthelot JM; Rhumatologie, CHU Hôtel-Dieu, 44093 Nantes, France., Dieude P; Rhumatologie, hôpital Bichat-Claude Bernard, 75018 Paris, France., Dubost JJ; Rhumatologie, CHU Gabriel-Montpied, 63003 Clermont-Ferrand, France., Fauchais AL; Médecine interne, CHU de Limoges Dupuytren, 87042 Limoges, France., Goeb V; Rhumatologie, CHU Amiens-Picardie Site Nord, 80054 Amiens, France., Hachulla E; Service de médecine interne et immunologie clinique, centre de référence des maladies rares autoimmunes rares (CeRAINO), université de Lille, CHU, 59100 Lille, France., Hatron PY; Service de médecine interne et immunologie clinique, centre de référence des maladies rares autoimmunes rares (CeRAINO), université de Lille, CHU, 59100 Lille, France., Larroche C; Médecine interne H5, hôpital Avicenne, CHU, 93000 Bobigny, France., Hayem G; Service de rhumatologie, CHU Ambroise Paré, 92100 Boulogne-Billancourt, France., Le Guern V; Médecine interne, hôpital Cochin, 75679 Paris, France., Perdriger A; Rhumatologie, hôpital Sud, 35200 Rennes, France., Morel J; Immuno-rhumatologie, CHU Lapeyronie, 34000 Montpellier, France., Vittecoq O; Rhumatologie, CHU Rouen, 76000 Bois-Guillaume, France., Mariette X; Rhumatologie, université Paris Sud XI, AP-HP, 94270 Le Kremlin-Bicêtre, France., Devauchelle-Pensec V; Inserm 1227, LabEx IGO, rhumatologie, centre de référence maladies rares CERAINO, université de Bretagne Occidentale, CHU de Brest, 29200 Brest, France., Saraux A; Inserm 1227, LabEx IGO, rhumatologie, centre de référence maladies rares CERAINO, université de Bretagne Occidentale, CHU de Brest, 29200 Brest, France. Electronic address: alain.saraux@chu-brest.fr.
Jazyk: angličtina
Zdroj: Joint bone spine [Joint Bone Spine] 2021 Jul; Vol. 88 (4), pp. 105162. Date of Electronic Publication: 2021 Feb 19.
DOI: 10.1016/j.jbspin.2021.105162
Abstrakt: Objective: To determine the prevalence and significance of dermatological disorders in primary Sjögren syndrome (pSS).
Methods: We used 2 pSS French cohorts (ASSESS, in which prevalence of skin disorders in 395 patients was evaluated; and diapSS, in which 76 on 139 pSS patients had an examination by a dermatologist) and baseline data of the TEARS randomized trial (110 patients with recent or active pSS treated with rituximab or placebo and evaluated for skin dryness using a visual analogue scale (VAS) out of 100).
Results: Skin manifestations included in the EULAR Sjögren syndrome disease activity index (ESSDAI) were rare in the ASSESS cohort (n=16/395, 4.1%, mainly purpuras; only 3 had high activity), but they were associated with activity in the other ESSDAI domains (peripheral neurological (P<0.001), muscular (P<0.01), haematological (P<0.05), biological (P<0.05), history of arthritis (P<0.01), splenomegaly (P<0.05) and higher gamma globulin levels (P<0.01)). In the diapSS cohort, compared to pSS patients not receiving a dermatological consultation, the pSS patients who had a dermatological consultation had significantly more dermatological involvement outside the ESSDAI score [38.2% (29/76) versus 15.9% (10/63); P<0.01]. The TEARS study showed a high prevalence of cutaneous dryness (VAS>50; 48.2%) and found that patients with dry skin had higher VAS pain (P<0.01) and drought (P<0.01) scores.
Conclusion: ESSDAI skin activity is rare and associated with hypergammaglobulinemia and ESSDAI activity. Systematic dermatological examination is informative for non-specific lesions. The most common skin disorder is skin dryness, which is associated with a higher pain and overall subjective dryness.
(Copyright © 2021 Société française de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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