Removal of vasopressin cells from the paraventricular nucleus of the hypothalamus enhances lipopolysaccharide-induced sickness behaviour in mice.

Autor: Whylings J; Neuroscience Institute, Georgia State University, Atlanta, GA, USA., Rigney N; Neuroscience Institute, Georgia State University, Atlanta, GA, USA., de Vries GJ; Neuroscience Institute, Georgia State University, Atlanta, GA, USA.; Department of Biology, Georgia State University, Atlanta, GA, USA., Petrulis A; Neuroscience Institute, Georgia State University, Atlanta, GA, USA.
Jazyk: angličtina
Zdroj: Journal of neuroendocrinology [J Neuroendocrinol] 2021 Jan; Vol. 33 (1), pp. e12915. Date of Electronic Publication: 2020 Dec 07.
DOI: 10.1111/jne.12915
Abstrakt: Vasopressin (AVP) cells in the paraventricular nucleus of the hypothalamus (PVN) are activated during sickness and project to multiple nuclei responsible for the anxiety, social and motivated behaviours affected during sickness, suggesting that these cells may play a role in sickness behaviours, typically expressed as reduced mobility, increased anxiety, anhedonia and social withdrawal. In the present study, we selectively ablated AVP neurones in the PVN of male and female mice (Mus musculus) and induced sickness behaviour via injection of bacterial lipopolysaccharide (LPS). We found that PVN AVP ablation increased the effects of LPS, specifically by further decreasing sucrose preference in males and females and decreasing the social preference of males, monitored within 24 hours of LPS injection. These results suggest that PVN AVP contributes to the change in motivated behaviours during sickness and may help promote recovery from infection..
(© 2020 British Society for Neuroendocrinology.)
Databáze: MEDLINE
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