The IL-27 receptor regulates TIGIT on memory CD4 + T cells during sepsis.

Autor:	Morrow KN; Immunology and Molecular Pathogenesis Program, Laney Graduate School, Emory University, Atlanta, GA 30324, USA.; Department of Surgery, Emory University School of Medicine, Atlanta, GA 30324, USA., Liang Z; Department of Surgery, Emory University School of Medicine, Atlanta, GA 30324, USA., Xue M; Department of Surgery, Emory University School of Medicine, Atlanta, GA 30324, USA.; Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China., Chihade DB; Department of Surgery, Emory University School of Medicine, Atlanta, GA 30324, USA., Sun Y; Department of Surgery, Emory University School of Medicine, Atlanta, GA 30324, USA.; Department of Critical Care Medicine, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang 110000, China., Chen CW; Immunology and Molecular Pathogenesis Program, Laney Graduate School, Emory University, Atlanta, GA 30324, USA.; Department of Surgery, Emory University School of Medicine, Atlanta, GA 30324, USA., Coopersmith CM; Department of Surgery, Emory University School of Medicine, Atlanta, GA 30324, USA.; Emory Critical Care Center, Emory University School of Medicine, Atlanta, GA 30324, USA., Ford ML; Department of Surgery, Emory University School of Medicine, Atlanta, GA 30324, USA.; Emory Transplant Center, Emory University School of Medicine, Atlanta, GA 30324, USA.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2021 Jan 27; Vol. 24 (2), pp. 102093. Date of Electronic Publication: 2021 Jan 27 (Print Publication: 2021).
DOI:	10.1016/j.isci.2021.102093
Abstrakt:	Sepsis is a leading cause of morbidity and mortality associated with significant impairment in memory T cells. These changes include the upregulation of co-inhibitory markers, a decrease in functionality, and an increase in apoptosis. Due to recent studies describing IL-27 regulation of TIGIT and PD-1, we assessed whether IL-27 impacts these co-inhibitory molecules in sepsis. Based on these data, we hypothesized that IL-27 was responsible for T cell dysfunction during sepsis. Using the cecal ligation and puncture (CLP) sepsis model, we found that IL-27Rα was associated with the upregulation of TIGIT on memory CD4 + T cells following CLP. However, IL-27 was not associated with sepsis mortality. Competing Interests: The authors declare no competing interests. (© 2021 The Authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu