APOL1 Risk Variants and Subclinical Cardiovascular Disease in Incident Hemodialysis Patients.

Autor:	Chen TK; Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA., Fitzpatrick J; Departments of Pediatrics and Medicine, Hospital for Sick Children, University Health Network and University of Toronto, Toronto, Ontario, Canada., Winkler CA; Basic Research Program, Frederick National Laboratory, Frederick, Maryland, USA., Binns-Roemer EA; Basic Research Program, Frederick National Laboratory, Frederick, Maryland, USA., Corona-Villalobos CP; Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Jaar BG; Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.; Nephrology Center of Maryland, Baltimore, Maryland, USA., Sozio SM; Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Parekh RS; Departments of Pediatrics and Medicine, Hospital for Sick Children, University Health Network and University of Toronto, Toronto, Ontario, Canada., Estrella MM; Kidney Health Research Collaborative, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.; San Francisco VA Health Care System, San Francisco, California, USA.
Jazyk:	angličtina
Zdroj:	Kidney international reports [Kidney Int Rep] 2020 Nov 20; Vol. 6 (2), pp. 333-341. Date of Electronic Publication: 2020 Nov 20 (Print Publication: 2021).
DOI:	10.1016/j.ekir.2020.11.006
Abstrakt:	Introduction: To better understand the impact of APOL1 risk variants in end-stage renal disease (ESRD) we evaluated associations of APOL1 risk variants with subclinical cardiovascular disease (CVD) and mortality among African Americans initiating hemodialysis and enrolled in the Predictors of Arrhythmic and Cardiovascular Risk in ESRD cohort study. Methods: We modeled associations of APOL1 risk status (high = 2; low = 0/1 risk alleles) with baseline subclinical CVD (left ventricular [LV] hypertrophy; LV mass; ejection fraction; coronary artery calcification [CAC]; pulse wave velocity [PWV]) using logistic and linear regression and all-cause or cardiovascular mortality using Cox models, adjusting for age, sex, and ancestry. In sensitivity analyses, we further adjusted for systolic blood pressure and Charlson Comorbidity Index. Results: Of 267 African American participants successfully genotyped for APOL1 , 27% were high-risk carriers, 41% were women, and mean age was 53 years. At baseline, APOL1 high- versus low-risk status was independently associated with 50% and 53% lower odds of LV hypertrophy and CAC, respectively, and 10.7% lower LV mass. These associations were robust to further adjustment for comorbidities but not systolic blood pressure. APOL1 risk status was not associated with all-cause or cardiovascular mortality (mean follow-up 2.5 years). Conclusion: Among African American patients with incident hemodialysis, APOL1 high-risk status was associated with better subclinical measures of CVD but not mortality. (© 2020 International Society of Nephrology. Published by Elsevier Inc.)
Databáze:	MEDLINE
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