Is there a link between pre-existing antibodies acquired due to childhood vaccinations or past infections and COVID-19? A case control study.

Autor:	Sumbul B; Department of Medical Microbiology, Bezmialem Vakıf University, Faculty of Medicine, Istanbul, Turkey., Sumbul HE; Department of Internal Medicine, University of Health Sciences, Adana Health Practice and Research Center, Adana, Turkey., Okyay RA; Department of Public Health, Kahramanmaraş Sütçü İmam University, Faculty of Medicine, Kahramanmaraş, Turkey., Gülümsek E; Department of Internal Medicine, University of Health Sciences, Adana Health Practice and Research Center, Adana, Turkey., Şahin AR; Department of Infectious Diseases and Clinical Microbiology, Kahramanmaraş Sütçü İmam University, Faculty of Medicine, Kahramanmaraş, Turkey., Boral B; Department of Microbiology, University of Health Sciences, Adana Health Practice and Research Center, Adana, Turkey., Koçyiğit BF; Department of Physical Medicine and Rehabilitation, Kahramanmaraş Sütçü İmam University, Faculty of Medicine, Kahramanmaraş, Turkey., Alfishawy M; Infectious Diseases Consultants and Academic Researchers of Egypt (IDCARE), Cairo, Egypt., Gold J; World Organization, Watkinsville, GA, USA., Tasdogan AM; Department of Anesthesiology and Reanimation, Hasan Kalyoncu University, Faculty of Health Sciences, Gaziantep, Turkey.
Jazyk:	angličtina
Zdroj:	PeerJ [PeerJ] 2021 Feb 09; Vol. 9, pp. e10910. Date of Electronic Publication: 2021 Feb 09 (Print Publication: 2021).
DOI:	10.7717/peerj.10910
Abstrakt:	Background: There is growing evidence indicating that children are less affected from COVID-19. Some authors speculate that childhood vaccinations may provide some cross-protection against COVID-19. In this study, our aim was to compare the circulating antibody titers for multiple childhood vaccine antigens, as an indicator of the state of immune memory between patients with COVID-19 and healthy controls, with a specific aim to identify the association between disease severity and antibody titrations which may indicate a protective function related to vaccine or disease induced memory. Methods: This study is a case-control study including 53 patients with COVID-19 and 40 healthy volunteers. COVID-19 severity was divided into three groups: asymptomatic, mild and severe. We measured the same set of antibody titers for vaccine antigens, and a set of biochemical and infection markers, in both the case and control groups. Results: Rubella ( p = 0.003), pneumococcus ( p = 0.002), and Bordetella pertussis ( p < 0.0001) titers were found to be significantly lower in the case group than the control group. There was a significant decline in pneumococcus titers with severity of disease ( p = 0.021) and a significant association with disease severity for Bordetella pertussis titers ( p = 0.014) among COVID patients. Levels of AST, procalcitonin, ferritin and D-dimer significantly increased with the disease severity. Discussion: Our study supports the hypothesis that pre-existing immune memory, as monitored using circulating antibodies, acquired from childhood vaccinations, or past infections confer some protection against COVID-19. Randomized controlled studies are needed to support a definitive conclusion. Competing Interests: The authors declare that they have no competing interests. (© 2021 Sumbul et al.)
Databáze:	MEDLINE
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