| Autor: |
Alotaibi B; Pharmaceutical Sciences Department, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., El-Masry TA; Pharmaceutical Sciences Department, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia/Departement of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt., Tousson E; Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt., Alarfaj SJ; Pharmaceutical Practice Department, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia., Saleh A; Pharmaceutical Sciences Department, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia/Department of Biochemistry, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt. |
| Abstrakt: |
Hydroxyapatite is bio-ceramic materials with a calcium to phosphorus proportion like to that of normal bone and teeth. The current study meant to examine the cardiac toxicity by hydroxyapatite nanoparticles (HAP NPs) and the protective effect of the rocket seeds in treatments. An aggregate of 40 male Wistar rodents were partitioned into 4 equal groups [Gp1, control; Gp2, rocket seeds extract (RS); Gp3, HAP NPs; Gp4, HAP NPs+RS]. Current results exhibit that; HAP NPs induce a significant increase in myoglobin, LDH (lactate dehydrogenase), CK-MB (creatinine kinase) and CK (creatinine kinase) levels, cardiac thiobarbituric acid-reactive substances (TBARS), injury and P53 expressions. In contrast; a significant reduction in cardiac catalase, reduced glutathione (GSH) and superoxide dismutase (SOD) as compared to control group. Post treatment of rat with HAP NPs and rocket seeds extract (HAP NPs+RS) improved the cardiac functions and structure. Rocket seeds extract may offer advantages against the harmful effects of hydroxyapatite nanoparticles. |
