Lipid/polymer-based nanocomplexes in nucleic acid delivery as cancer vaccines.

Autor: Beg S; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. Electronic address: sarwar.beg@gmail.com., Almalki WH; Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Khatoon F; Department of Biochemistry, College of Medicine, University of Hail, Saudi Arabia., Alharbi KS; Department of Pharmacology, College of Pharmacy, Jouf University, Sakakah, Saudi Arabia., Alghamdi S; Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia., Akhter MH; Faculty of Pharmacy, DIT University, Dehradun, India., Khalilullah H; Department of Pharmaceutical Chemistry and Pharmacognosy, Unaizah College of Pharmacy, Qassim University, Saudi Arabia., Baothman AA; Ministry of National Guard-Health Affairs, King Saud Bin Abdulaziz University for Health Science (KSAU-HS), King Abdullah International Medical Research Center (KAIMARC), Saudi Arabia., Hafeez A; Glocal School of Pharmacy, Glocal University, Mirzapur Pole, Sahranpur, Uttar Pradesh, India., Rahman M; Department of Pharmaceutical Sciences, SIHAS, Faculty of Health Science, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, India. Electronic address: mahfoozkaifi@gmail.com., Akhter S; New Product Development, Global R&D, Sterile ops, TEVA Pharmaceutical Industries Ltd., Aston Ln N, Halton, Preston Brook, Runcorn WA7 3FA, UK; Centre de Biophysique Moléculaire, CNRS UPR4301, Rue Charles Sadron, 45071 Orléans Cedex 2, France., Choudhry H; Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia.
Jazyk: angličtina
Zdroj: Drug discovery today [Drug Discov Today] 2021 Aug; Vol. 26 (8), pp. 1891-1903. Date of Electronic Publication: 2021 Feb 18.
DOI: 10.1016/j.drudis.2021.02.013
Abstrakt: Cancer vaccines consist of nucleic acid derivatives such as plasmid DNA, small interfering RNA and mRNA, and can be customized according to the patient's needs. Nanomedicines have proven to be exceptionally good as miniaturized drug carriers, and thus they offer great advantages for delivering cancer vaccines. This review provides an overview of the literature on cancer vaccines, from their inception to current developments in the field.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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