Oral and oropharyngeal diffuse large B-cell lymphoma and high-grade B-cell lymphoma: A clinicopathologic and prognostic study of 69 cases.

Autor: Rodrigues-Fernandes CI; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba/Brazil., Junior AG; Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., Soares CD; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba/Brazil., Morais TML; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba/Brazil., do Amaral-Silva GK; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba/Brazil., de Carvalho MGF; Private Pathology Service, Natal, Rio Grande do Norte, Brazil., de Souza LL; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba/Brazil; Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., Pires FR; Oral Pathology, Dental School, State University of Rio de Janeiro, Rio de Janeiro, Brazil., Dos Santos TCRB; Oral Pathology, Dental School, State University of Rio de Janeiro, Rio de Janeiro, Brazil., Pereira DL; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba/Brazil., Rivero LF; Department of Pathology, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Bezerra KT; Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., de Andrade BAB; Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Romañach MJ; Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Agostini M; Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Henao JR; Department of Pathology, University of Antioquia, Medellín, Colombia., Gabriel AF; Department of Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Dos Santos Pinto Júnior D; Department of Oral Diagnosis, Dental School, University of São Paulo, São Paulo, Brazil., Martins MD; Department of Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Pereira MJC; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Mesquita RA; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Gomez RS; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Souto GR; Department of Dentistry, Pontifícia Universidade Católica de Minas Gerais, Belo Horizonte, Brazil., Santos-Silva AR; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba/Brazil., Vargas PA; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba/Brazil; Department of Oral Biology and Oral Pathology, University of Pretoria, Pretoria, South Africa., Lopes MA; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba/Brazil., de Almeida OP; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba/Brazil., Pontes FSC; Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., Pontes HAR; Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., Burbano RMR; Private Pathology Service, Natal, Rio Grande do Norte, Brazil., Fonseca FP; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba/Brazil; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Department of Oral Biology and Oral Pathology, University of Pretoria, Pretoria, South Africa. Electronic address: Felipepfonseca@hotmail.com.
Jazyk: angličtina
Zdroj: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2021 Apr; Vol. 131 (4), pp. 452-462.e4. Date of Electronic Publication: 2020 Nov 20.
DOI: 10.1016/j.oooo.2020.11.005
Abstrakt: Objective: The objective of this study was to describe the clinicopathological, molecular, and prognostic features of oral/oropharyngeal diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma.
Study Design: All cases were retrieved from 7 Brazilian institutions. Immunohistochemical reactions were performed to confirm the diagnoses and to categorize the tumors. In situ hybridization was used to detect Epstein-Barr virus (EBV) and fluorescence in situ hybridization was used to identify gene rearrangements.
Results: Most cases involved the oral cavity (76.8%). Males and females, with a mean age of 60 years, were evenly affected. Tumors mostly presented as painful swellings. Forty cases represented germinal center B-cell type (58%). Five cases presented double-hit translocation and 3 harbored rearrangement for MYC/BCL2/BCL6. EBV was detected in 3 cases (4.3%). The 5-year overall survival was 44.4%. Female sex, presence of pain and ulcer, microscopic "starry sky pattern" and necrosis, co-expression of c-Myc/Bcl2, and translocation of MYC were associated with a lower survival in univariate analysis (P = .05, P = .01, P = .01, P = .03, P = .05, P = .006, P = .05, respectively).
Conclusion: Patients affected by oral/oropharyngeal DLBCL have a low survival rate. High-grade B-cell lymphoma (17.7%) and EBV-positive DLBCL, not otherwise specified (4.3%) account for a small number of cases.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: