Cancer as an infectious disease: A different treatment alternative using a combination of tigecycline and pyrvinium pamoate - An example of breast cancer.

Autor:	Huang SW; Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan., Sun MT; Department of Internal Medicine, Hualien Armed Forces General Hospital, Hualien 97144, Taiwan., Lee WS; Division of Infectious Diseases, Department of Internal Medicine, Wan Fang Medical Center, Taipei Medical University, Taipei 11608, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 10031, Taiwan., Su YS; Division of Infectious Diseases, Department of Internal Medicine, Wan Fang Medical Center, Taipei Medical University, Taipei 11608, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 10031, Taiwan; Pharmacology and Toxicology, School of Medicine, Tzu Chi University, Hualien, Taiwan., Lee YT; Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan., Chiang MH; Department and Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei 11490, Taiwan., Wang YC; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan., Yang YS; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan., Tzeng SC; Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan., Wu TY; Pharmacology and Toxicology, School of Medicine, Tzu Chi University, Hualien, Taiwan., Sun JS; Department of Orthopedics, National Taiwan University, Taipei 10022, Taiwan., Lin FH; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan; Department of Biomedical Engineering, National Taiwan University, Taipei 10617, Taiwan. Electronic address: double@ntu.edu.tw.
Jazyk:	angličtina
Zdroj:	Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [J Microbiol Immunol Infect] 2022 Feb; Vol. 55 (1), pp. 51-59. Date of Electronic Publication: 2021 Jan 13.
DOI:	10.1016/j.jmii.2020.12.008
Abstrakt:	Background: Tigecycline is an antibiotic that well tolerated for treating complicated infections. It has received attention as an anti-cancer agent and expected to solve two major obstacles, sides effects that accompany chemotherapy and drug resistance, in the breast cancer treatment. However, previous studies reported that the levels in the blood are typically low of tigecycline, so higher doses are needed to treat cancer, that may increase the risk of side effects. To achieve better anti-cancer effects for tigecycline, we need to find a novel adjunct agent. Methods: In this study, we used different concentration of pyrvinium pamoate combined with tigecycline to treat cell. And assess the effect of two drugs in inhibit cell proliferation, induce cell autophagy, or increase cell apoptosis to evaluate the consequent of combined therapy. Results: We observed that after the combined therapy, the cell cycle arrest at G1/s phase, the level of p21 increased, but decreased the levels of CDK2. Others, two drugs via different mechanisms to inhibit cancer cell proliferation and with selective cytotoxic to different cell lines. That could enhance the effect of breast cancer treatment. Conclusion: Combining low dose of tigecycline use with pyrvinium pamoate is a novel approach for breast cancer treatment. Appropriate combined therapy in breast cancer is recommended to improve outcomes. Other problems like drug resistance occur in patients or the microbes surrounding breast tissues would confer susceptibility to cancers then influence the effectiveness of treatment, which could be improved through combined therapy. (Copyright © 2021. Published by Elsevier B.V.)
Databáze:	MEDLINE
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