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Contributed Indexing:	Keywords: endothelial nitric oxide synthase; polymorphism; sepsis; susceptibility; tumor necrosis factor
Substance Nomenclature:	0 (Tumor Necrosis Factor-alpha) EC 1.14.13.39 (NOS3 protein, human) EC 1.14.13.39 (Nitric Oxide Synthase Type III)
Entry Date(s):	Date Created: 20210220 Date Completed: 20220120 Latest Revision: 20220120
Update Code:	20231215
DOI:	10.1002/jgm.3323
PMID:	33609421
Autor:	Özkan M; Department of Emergency Medicine, Medical School, Erciyes University, Kayseri, Turkey., Günay N; Department of Emergency Medicine, Medical School, Erciyes University, Kayseri, Turkey., Sener EF; Department of Medical Biology, Medical School, Erciyes University, Genome and Stem Cell Center, Kayseri, Turkey., Karcıoglu Ö; Department of Emergency Medicine, University of Health Sciences, Istanbul Education and Research Hospital, Istanbul, Turkey., Tahtasakal R; Department of Medical Biology, Medical School, Erciyes University, Genome and Stem Cell Center, Kayseri, Turkey., Dal F; Genome and Stem Cell Center of Erciyes University, Kayseri, Turkey., Günay NE; Clinics of Medical Biochemistry, Kayseri City Hospital, Kayseri, Turkey., Demiryürek AT; Department of Medical Pharmacology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
Jazyk:	angličtina
Zdroj:	The journal of gene medicine [J Gene Med] 2021 Apr; Vol. 23 (4), pp. e3323. Date of Electronic Publication: 2021 Feb 26.
DOI:	10.1002/jgm.3323
Abstrakt:	Background: Sepsis is a life-threatening condition caused by a dysregulated host response to infections and is a leading cause of death in hospitalized patients. The present study aimed to elucidate the possible association between sepsis and the tumor necrosis factor (TNF) gene -308G/A (rs1800629) polymorphism, as well as endothelial nitric oxide synthase (eNOS, NOS3) gene -786T/C (rs2070744), 4a/4b (27 bp-VNTR in intron 4, rs61722009) and 894G/T (Glu298Asp, rs1799983) polymorphisms. Methods: In total, 188 septic adult cases and 188 healthy controls were enrolled. Genomic DNAs from the controls and patients were analyzed by polymerase chain reaction and restriction fragment length polymorphism methods. Results: There were significant associations between the G/G genotype and G allele of the TNF -308G/A (rs1800629) polymorphism in the sepsis group (p < 0.001). The presence of the T/C genotype (p = 0.002) and C allele (p = 0.001) of the -786T/C (rs2070744) was markedly associated with an increased risk of sepsis. However, no significant associations were found with 4a/4b (27 bp-VNTR in intron 4, rs61722009) and 894G/T (Glu298Asp, rs1799983) polymorphisms. Higher 4bGC and lower 4bTT haplotype frequencies were associated with sepsis. Conclusions: Our results strongly suggest that TNF gene (-308G/A, rs1800629) and NOS3 gene -786T/C (rs2070744) polymorphisms may modify individual susceptibility to sepsis in the Turkish population. (© 2021 John Wiley & Sons, Ltd.)
Databáze:	MEDLINE
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