CT diagnosis of ilioinguinal lymph node metastases in melanoma using radiological characteristics beyond size and asymmetry.

Autor:	Wilkinson MJ; Department of Academic Surgery, Sarcoma and Melanoma Unit, The Royal Marsden Hospital, London, UK., Snow H; Department of Academic Surgery, Sarcoma and Melanoma Unit, The Royal Marsden Hospital, London, UK., Downey K; Department of Radiology, The Royal Marsden Hospital, London, UK., Thomas K; Statistics Department, The Royal Marsden Hospital, London, UK., Riddell A; Department of Radiology, The Royal Marsden Hospital, London, UK., Francis N; Department of Pathology, The Royal Marsden Hospital (Honorary) and Charing Cross Hospital, London, UK., Strauss DC; Department of Academic Surgery, Sarcoma and Melanoma Unit, The Royal Marsden Hospital, London, UK., Hayes AJ; Department of Academic Surgery, Sarcoma and Melanoma Unit, The Royal Marsden Hospital, London, UK.; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK., Smith MJF; Department of Academic Surgery, Sarcoma and Melanoma Unit, The Royal Marsden Hospital, London, UK., Messiou C; Department of Radiology, The Royal Marsden Hospital, London, UK.; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.
Jazyk:	angličtina
Zdroj:	BJS open [BJS Open] 2021 Jan 08; Vol. 5 (1).
DOI:	10.1093/bjsopen/zraa005
Abstrakt:	Background: Diagnosis of lymph node (LN) metastasis in melanoma with non-invasive methods is challenging. The aim of this study was to evaluate the diagnostic accuracy of six LN characteristics on CT in detecting melanoma-positive ilioinguinal LN metastases, and to determine whether inguinal LN characteristics can predict pelvic LN involvement. Methods: This was a single-centre retrospective study of patients with melanoma LN metastases at a tertiary cancer centre between 2008 and 2016. Patients who had preoperative contrast-enhanced CT assessment and ilioinguinal LN dissection were included. CT scans containing significant artefacts obscuring the pelvis were excluded. CT scans were reanalysed for six LN characteristics (extracapsular spread (ECS), minimum axis (MA), absence of fatty hilum (FH), asymmetrical cortical nodule (CAN), abnormal contrast enhancement (ACE) and rounded morphology (RM)) and compared with postoperative histopathological findings. Results: A total of 90 patients were included. Median age was 58 (range 23-85) years. Eighty-eight patients (98 per cent) had pathology-positive inguinal disease and, of these, 45 (51 per cent) had concurrent pelvic disease. The most common CT characteristics found in pathology-positive inguinal LNs were MA greater than 10 mm (97 per cent), ACE (80 per cent), ECS (38 per cent) and absence of RM (38 per cent). In multivariable analysis, inguinal LN characteristics on CT indicative of pelvic disease were RM (odds ratio (OR) 3.3, 95 per cent c.i. 1.2 to 8.7) and ECS (OR 4.2, 1.6 to 11.3). Cloquet's node is known to be a poor predictor of pelvic spread. Pelvic LN disease was present in 50 per cent patients, but only 7 per cent had a pathology-positive Cloquet's node. Conclusion: Additional CT radiological characteristics, especially ECS and RM, may improve diagnostic accuracy and aid clinical decisions regarding the need for inguinal or ilioinguinal dissection. (© The Author(s) 2021. Published by Oxford University Press on behalf of BJS Society Ltd.)
Databáze:	MEDLINE
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