CRISPR base editor screens identify variant function at scale.
| Autor: | Parrish PCR; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Berger AH; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Genome Sciences, University of Washington, Seattle, WA, USA. Electronic address: ahberger@fredhutch.org. |
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| Jazyk: | angličtina |
| Zdroj: | Molecular cell [Mol Cell] 2021 Feb 18; Vol. 81 (4), pp. 647-648. |
| DOI: | 10.1016/j.molcel.2021.01.036 |
| Abstrakt: | Cuella-Martin et al. (2021) and Hanna et al. (2021) showcase CRISPR base editing in large-scale pooled screens in human cells to discover both loss- and gain-of-function variants, enabling protein structure/function insights and clinical variant interpretation. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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