Losartan prevents bladder fibrosis and protects renal function in rat with neurogenic paralysis bladder.

Autor:	He YL; Pediatric Urodynamic Centre, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Joint International Pediatric Urodynamic Laboratory, Zhengzhou, China.; Pediatric surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Wen JG; Pediatric Urodynamic Centre, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Joint International Pediatric Urodynamic Laboratory, Zhengzhou, China., Pu QS; Pediatric Urodynamic Centre, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Joint International Pediatric Urodynamic Laboratory, Zhengzhou, China., Wen YB; Pediatric Urodynamic Centre, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Joint International Pediatric Urodynamic Laboratory, Zhengzhou, China., Zhai RQ; Pediatric Urodynamic Centre, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Joint International Pediatric Urodynamic Laboratory, Zhengzhou, China., Chen Y; Pediatric Urodynamic Centre, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Joint International Pediatric Urodynamic Laboratory, Zhengzhou, China., Ma Y; Pediatric Urodynamic Centre, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Joint International Pediatric Urodynamic Laboratory, Zhengzhou, China., Liu EP; Pediatric Urodynamic Centre, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Joint International Pediatric Urodynamic Laboratory, Zhengzhou, China., Xing D; Pediatric Urodynamic Centre, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Joint International Pediatric Urodynamic Laboratory, Zhengzhou, China., Ji FP; Pediatric Urodynamic Centre, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Joint International Pediatric Urodynamic Laboratory, Zhengzhou, China., Yang XH; Pediatric Urodynamic Centre, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Henan Joint International Pediatric Urodynamic Laboratory, Zhengzhou, China., Wang QW; Pediatric Urodynamic Centre, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Wang Y; Pediatric Urodynamic Centre, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Bauer SB; Department of Urology, Boston Children's Hospital, Boston, Massachusetts, USA.
Jazyk:	angličtina
Zdroj:	Neurourology and urodynamics [Neurourol Urodyn] 2021 Jan; Vol. 40 (1), pp. 137-146.
DOI:	10.1002/nau.24567
Abstrakt:	Aims: To investigate the effect of losartan on preventing bladder fibrosis and protecting renal function in rats with neurogenic paralysis bladder (NPB). Materials and Methods: Rats were assigned to the transecting spinal nerves group (TSNG), transecting spinal nerves + losartan group (LSTG), and control group (CG). On Day 32 postsurgery, bladder capacity (BC), bladder compliance (ΔC), bladder leakage pressure (P ves.leak ) of TSNG and LSTG while BC, ΔC, and bladder threshold pressure (P ves.thre ) of CG were measured by cystometry in each cohort. Renal function and the expression quantity of Angiotensin Ⅱ (Ang II) in blood were detected, in addition Ang II, Ang II Type 1 receptor (AT1), transformation growth factor β1 (TGFβ1), Collagen Ⅲ, and collagen fibrin in the bladder tissue were detected too. Results: ΔC in TSNG and LSTG decreased significantly compared to the CG. P ves.leak in TSNG and LSTG were significantly higher than P ves.thre in CG. Renal function of both TSNG and LSTG decreased significantly compared with the CG, but renal function in LSTG was better than in TSNG. Ang Ⅱ in blood and bladder tissue in TSNG and LSTG increased significantly compared with CG. AT1 was expressed in the bladder tissue of all rats. The TGFβ1, Collagen Ⅲ, and collagen fibrin expression level increased significantly in TSNG compared with LSTG and CG, while these levels were not significantly different between CG and LSTG. Conclusion: Losartan might prevent NPB fibrosis by stopping the upregulated signaling of Ang II/AT1/TGFβ1 and consequently may reduce kidney damage from occurring. (© 2021 Wiley Periodicals LLC.)
Databáze:	MEDLINE
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