Fibroblast involvement in cardiac remodeling and repair under ischemic conditions.

Autor: Ceauşu Z; Department of Pathology, 'Sf. Pantelimon' Emergency Hospital, 021659 Bucharest, Romania., Socea B; Department of Surgery, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Surgery, 'Sf. Pantelimon' Emergency Hospital, 021659 Bucharest, Romania., Costache M; Department of Pathology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Pathology, University Emergency Hospital, 050098 Bucharest, Romania., Predescu D; Department of Surgery, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Surgery, 'Sf. Maria' Hospital, 011172 Bucharest, Romania., Şerban D; Department of Surgery, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Surgery, University Emergency Hospital, 050098 Bucharest, Romania., Smarandache CG; Department of Surgery, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Surgery, University Emergency Hospital, 050098 Bucharest, Romania., Pacu I; Department of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Obstetrics and Gynecology, 'Sf. Pantelimon' Emergency Hospital, 021659 Bucharest, Romania., Alexandru HH; Department of Obstetrics and Gynecology, 'Sf. Pantelimon' Emergency Hospital, 021659 Bucharest, Romania.; PhD Fellowship, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania., Daviţoiu AM; Department of Pediatrics, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Pediatrics, 'Doctor Victor Gomoiu' Emergency Children Clinical Hospital, 022102 Bucharest, Romania., Jacotă-Alexe F; Department of Obstetrics and Gynecology, 'Sf. Pantelimon' Emergency Hospital, 021659 Bucharest, Romania., Cîrstoveanu C; Department of Pediatrics, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Pediatrics, 'Maria Sklodowska Curie' Emergency Children Clinical Hospital, 041451 Bucharest, Romania., Dimitriu MCT; Department of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Obstetrics and Gynecology, 'Sf. Pantelimon' Emergency Hospital, 021659 Bucharest, Romania., Pleş L; Department of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; Department of Obstetrics and Gynecology, 'Sf. Ioan' Hospital-Bucur, 040294 Bucharest, Romania., Ceauşu M; Department of Pathology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Jazyk: angličtina
Zdroj: Experimental and therapeutic medicine [Exp Ther Med] 2021 Mar; Vol. 21 (3), pp. 269. Date of Electronic Publication: 2021 Jan 25.
DOI: 10.3892/etm.2021.9700
Abstrakt: Cardiac fibroblasts play a main role in the physiological turnover of the extracellular matrix, as well as its pathological remodeling. A study was performed on a batch of 23 cases who died of various cardiac complications secondary to scarring myocardial infarctions. The aim of the study was to assess the fibroblast involvement in cardiac repair under ischemic conditions after myocardial infarction. Tissue myocardial samples from the left ventricle were taken from these cases for microscopy examination, in order to investigate the type and degree of fibrosis as well as the presence of cardiac interstitial fibroblasts. Multiple series of histological sections were also performed and examined, along with immunohistochemical analysis. The fibroblasts were diffusely distributed in the interstitium among the residual cardiomyocytes, showing variable expression of vimentin and smooth muscle actin. During cardiac remodeling, there was a successive interstitial deposition, first of reticulin fibers and then of collagen fibers, leading to interstitial fibrosis and myocardial replacement. There was a correlation between vimentin and smooth muscle actin expression and collagen deposition. Fibrosis with cardiac remodeling is based on maintaining proliferation capacity of the fibroblast and its capacity of protein synthesis in the extracellular matrix. Under hypoxic ischemic conditions, followed by myocardial infarction, the fibroblast switches phenotype and transdifferentiate into myofibroblast, contributing to the healing by secreting extracellular matrix proteins and collagen deposition, with subsequent cardiac remodeling and regulation of the micro-environment metabolism.
(Copyright © 2020, Spandidos Publications.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje