Elevated neutrophil-lymphocyte ratios in extremely preterm neonates with histologic chorioamnionitis.

Autor: Singareddy A; Department of Pediatrics, Saint Louis University School of Medicine, St Louis, MO, USA., Lee ASE; Department of Pediatrics, Saint Louis University School of Medicine, St Louis, MO, USA., Sweeney PL; University of Tennessee-Memphis School of Medicine, Memphis, TN, USA., Finkle AE; Department of Pediatrics, Saint Louis University School of Medicine, St Louis, MO, USA., Williams HL; SSM Health Cardinal Glennon Children's Hospital, St. Louis, MO, USA., Buchanan PM; Department of Pediatrics, Saint Louis University School of Medicine, St Louis, MO, USA.; Department of Health and Clinical Outcomes Research, Saint Louis University School of Medicine, St Louis, MO, USA., Hillman NH; Department of Pediatrics, Saint Louis University School of Medicine, St Louis, MO, USA., Koenig JM; Department of Pediatrics, Saint Louis University School of Medicine, St Louis, MO, USA. joyce.koenig@health.slu.edu.; Department of Molecular Microbiology & Immunology, Saint Louis University School of Medicine, St Louis, MO, USA. joyce.koenig@health.slu.edu.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2021 Jun; Vol. 41 (6), pp. 1269-1277. Date of Electronic Publication: 2021 Feb 18.
DOI: 10.1038/s41372-021-00964-4
Abstrakt: Objective: Histologic chorioamnionitis (HCA) is a placental inflammation linked to preterm birth and adverse neonatal outcome. The neutrophil-lymphocyte ratio (NLR) can identify various inflammatory disorders, however its utility in HCA is not clear. Our goal was to examine NLR values and HCA diagnoses in at-risk pregnancies and neonates.
Study Design: We retrospectively analyzed the EHR of mothers and preterm (<33 wk GA) neonates with or without HCA (identified by placental histology). The NLR was calculated from complete blood counts in laboring women and in their neonates (0-24 h of life).
Result: In 712 consecutive gestations, 50.8% had HCA (26.5% fetal HCA). The neonatal NLR (0-12 h, 13-24 h) predicted fetal HCA better than chance alone (p = 0.01 and 0.002, respectively).
Conclusion: Early NLR elevation in preterm neonates is consistent with a diagnosis of fetal HCA. The NLR may identify preterm neonates at risk for HCA-related complications.
Databáze: MEDLINE
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