Oxygen-Releasing Biomaterials: Current Challenges and Future Applications.

Autor: Willemen NGA; Department of Developmental BioEngineering, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, 7522 NB, Enschede, The Netherlands; Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, MA 02139, USA., Hassan S; Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, MA 02139, USA., Gurian M; Department of Developmental BioEngineering, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, 7522 NB, Enschede, The Netherlands., Li J; Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, MA 02139, USA; School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan, 430205, China., Allijn IE; Department of Developmental BioEngineering, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, 7522 NB, Enschede, The Netherlands., Shin SR; Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, MA 02139, USA. Electronic address: sshin4@bwh.harvard.edu., Leijten J; Department of Developmental BioEngineering, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Drienerlolaan 5, 7522 NB, Enschede, The Netherlands. Electronic address: jeroen.leijten@utwente.nl.
Jazyk: angličtina
Zdroj: Trends in biotechnology [Trends Biotechnol] 2021 Nov; Vol. 39 (11), pp. 1144-1159. Date of Electronic Publication: 2021 Feb 16.
DOI: 10.1016/j.tibtech.2021.01.007
Abstrakt: Oxygen is essential for the survival, function, and fate of mammalian cells. Oxygen tension controls cellular behaviour via metabolic programming, which in turn controls tissue regeneration, stem cell differentiation, drug metabolism, and numerous pathologies. Thus, oxygen-releasing biomaterials represent a novel and unique strategy to gain control over a variety of in vivo processes. Consequently, numerous oxygen-generating or carrying materials have been developed in recent years, which offer innovative solutions in the field of drug efficiency, regenerative medicine, and engineered living systems. In this review, we discuss the latest trends, highlight current challenges and solutions, and provide a future perspective on the field of oxygen-releasing materials.
Competing Interests: Conflicts of Interest The authors declare no conflict of interest.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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