Hyperhomocysteinemia and its relations to conventional risk factors for cardiovascular diseases in adult Nigerians: the REMAH study.

Autor: Chori BS; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, University of Abuja, Abuja, Nigeria.; Circulatory Health Research Laboratory, Old Anatomy Block (Beside School of Nursing and Midwifery), University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria., Danladi B; Circulatory Health Research Laboratory, Old Anatomy Block (Beside School of Nursing and Midwifery), University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria., Inyang BA; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, University of Abuja, Abuja, Nigeria., Okoh MP; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, University of Abuja, Abuja, Nigeria., Nwegbu MM; Department of Chemical Pathology, College of Health Sciences, Faculty of Basic Clinical Sciences, University of Abuja, Abuja, Nigeria., Alli AL; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, University of Abuja, Abuja, Nigeria., Odili AN; Circulatory Health Research Laboratory, Old Anatomy Block (Beside School of Nursing and Midwifery), University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria. augustine.odili@uniabuja.edu.ng.
Jazyk: angličtina
Zdroj: BMC cardiovascular disorders [BMC Cardiovasc Disord] 2021 Feb 18; Vol. 21 (1), pp. 102. Date of Electronic Publication: 2021 Feb 18.
DOI: 10.1186/s12872-021-01913-x
Abstrakt: Background: Evidence linking homocysteine (Hcy) with cardiovascular diseases (CVD) or its risk factors are limited in a sub-Saharan black population.
Objective: We set out to evaluate the association between Hcy and hypertension and other CVD risk factors in a population of adult Nigerians.
Methods: Data of 156 adults aged 18-70 years was accessed from the North Central study site of the REmoving the MAsk on Hypertension (REMAH) study. Homocysteine, blood glucose and lipid profile in whole blood/serum were measured using standard laboratory methods. Hypertension was diagnosed if average of 5 consecutive blood pressure (BP) measurements obtained using a mercury sphygmomanometer was equal to or higher than 140 systolic and/or 90 mmHg diastolic or the individual is on antihypertensive medication. Hyperhomocysteinemia (HHcy) was defined as Hcy > 10 µmol/L.
Results: Of the 156 participants, 72 (43.5%) were hypertensive, of whom 18 had HHcy. Subjects with HHcy were significantly (p < 0.05) older (41.5 vs. 40.6yrs), had lower HDL-cholesterol (0.6 vs. 0.8 mmol/L) and higher systolic (145.5 vs. 126.0 mmHg) and diastolic BP (92.9 vs. 79.6 mmHg), compared to those without HHcy. Intake of alcohol and a 1 yr increase in age were respectively and significantly (p < 0.05) associated with a 1.54 and 0.10 µmol/L increase in Hcy. In a multivariable model adjusted for age, sex and body mass index, a 1 µmol/L increase in Hcy, was associated with a 1.69 mmHg and 1.34 mmHg increase in systolic and diastolic pressure (p < 0.0001) respectively; and a 0.01 mmol/L decrease in HDL-cholesterol (p < 0.05).
Conclusion: HHcy occurs among hypertensive Nigerians and it is independently associated with age, HDL-cholesterol, systolic and diastolic BP.
Databáze: MEDLINE
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