Zika virus infection in pregnant travellers and impact on childhood neurodevelopment in the first two years of life: A prospective observational study.

Autor:	Marbán-Castro E; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain., Goncé A; Department of Maternal-Fetal Medicine, BCNatal - Barcelona Center of Maternal-Fetal and Neonatal Medicine, Hospital Clínic and Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain., Fumadó V; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain; Department of Tropical Pathology and Imported Diseases, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain., Martínez MJ; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Hospital Clínic, Barcelona, Spain., López M; Department of Maternal-Fetal Medicine, BCNatal - Barcelona Center of Maternal-Fetal and Neonatal Medicine, Hospital Clínic and Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain., García-Otero L; Department of Maternal-Fetal Medicine, BCNatal - Barcelona Center of Maternal-Fetal and Neonatal Medicine, Hospital Clínic and Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain., Salazar L; Department of Maternal-Fetal Medicine, BCNatal - Barcelona Center of Maternal-Fetal and Neonatal Medicine, Hospital Clínic and Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain., Esteve C; Department of Maternal-Fetal Medicine, BCNatal - Barcelona Center of Maternal-Fetal and Neonatal Medicine, Hospital Clínic and Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain., Salvia D; Department of Maternal-Fetal Medicine, BCNatal - Barcelona Center of Maternal-Fetal and Neonatal Medicine, Hospital Clínic and Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain., Fortuny C; Department of Tropical Pathology and Imported Diseases, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain., Eixarch E; Department of Maternal-Fetal Medicine, BCNatal - Barcelona Center of Maternal-Fetal and Neonatal Medicine, Hospital Clínic and Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain., Fuente-Moreno M; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain., Pinazo MJ; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Oliveira I; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain., Rodríguez-Valero N; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain., Requena-Méndez A; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain; Department of Global Public Health, Karolinska Institutet, Sweden., Camprubí D; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain., Saco A; Department of Pathology, Hospital Clínic, Barcelona, Spain., Castillo P; Department of Pathology, Hospital Clínic, Barcelona, Spain., Vázquez A; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain., de Ory F; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain., Navero-Castillejos J; Department of Clinical Microbiology, Hospital Clínic, Barcelona, Spain., Casellas A; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain., González R; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Muñoz J; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Gascón J; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Ordi J; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Global Public Health, Karolinska Institutet, Sweden., Menéndez C; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique., Bardají A; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique. Electronic address: azucena.bardaji@isglobal.org.
Jazyk:	angličtina
Zdroj:	Travel medicine and infectious disease [Travel Med Infect Dis] 2021 Mar-Apr; Vol. 40, pp. 101985. Date of Electronic Publication: 2021 Feb 15.
DOI:	10.1016/j.tmaid.2021.101985
Abstrakt:	Background: The emergence of Zika virus (ZIKV) represents a threat with consequences on maternal and children's health. We aimed to assess the clinical and epidemiological characteristics of pregnant women returning from ZIKV affected areas, and the effects of maternal ZIKV infection on birth outcomes and children's health. Methods: This was a hospital-based prospective observational study conducted at the Hospital Clínic of Barcelona and Hospital Sant Joan de Déu, Barcelona, Spain, from January 2016 to February 2020. Results: One hundred and ninety-five pregnant women who had travelled to ZIKV affected areas during pregnancy were recruited. Four women (2.1%) had a confirmed ZIKV infection, 40 women (20.5%) a probable infection, and 151 (77.4%) were negative for ZIKV. Among the ZIKV confirmed cases, a pregnant woman suffered a miscarriage, highly plausible to be associated with ZIKV infection. Brain cysts and microcalcifications were detected in 7% of fetuses or infants from women with confirmed or probable ZIKV infection. Neurodevelopmental delay in the language function was found in 33.3% out of the 21 children evaluated. Conclusions: These findings contribute to the understanding of ZIKV prevalence estimates, and the impact of maternal ZIKV infection on pregnancy outcomes and children's health. Results highlight the importance of long-term surveillance in pregnant travellers and their children. (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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