Oral and ocular late effects in head and neck cancer patients treated with radiotherapy.

Autor: Westgaard KL; Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway.; Division for Head, Neck and Reconstructive Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, Oslo University Hospital, Oslo, Norway., Hynne H; Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway., Amdal CD; Section for Head and Neck Oncology, Department of Oncology, Oslo University Hospital, Oslo, Norway., Young A; Department of Cariology and Gerodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway., Singh PB; Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway.; Division for Head, Neck and Reconstructive Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, Oslo University Hospital, Oslo, Norway., Chen X; Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway., Rykke M; Department of Cariology and Gerodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway., Hove LH; Department of Cariology and Gerodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway., Aqrawi LA; Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway., Utheim TP; Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway., Herlofson BB; Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway.; Division for Head, Neck and Reconstructive Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, Oslo University Hospital, Oslo, Norway., Jensen JL; Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway. j.c.l.jensen@odont.uio.no.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Feb 17; Vol. 11 (1), pp. 4026. Date of Electronic Publication: 2021 Feb 17.
DOI: 10.1038/s41598-021-83635-w
Abstrakt: A broader understanding of oral and ocular late effects in head and neck cancer (HNC) patients who underwent intensity-modulated radiotherapy (IMRT) may provide valuable information in follow-up and improve quality of life. Twenty-nine HNC patients treated at least 6 months earlier and 30 age-matched controls were recruited. After completing several questionnaires: Oral Health Impact Profile-14 (OHIP-14), Shortened Xerostomia Inventory (SXI), Ocular Surface Disease Index (OSDI) and McMonnies Dry Eye questionnaire (MDEQ), participants underwent oral and ocular examinations. Oral examination included clinical oral dryness score (CODS) and secretion rates of unstimulated and stimulated saliva (UWS, SWS). Ocular examination included tear film break-up time, Schirmer test and ocular surface staining. The patients had more problems related to dry mouth than controls based on CODS and SXI, and more complaints of dry eye disease based on OSDI and MDEQ. UWS and SWS rates and oral health related quality of life were significantly lower in the patient group. Subjective oral dryness (SXI) correlated significantly with subjective ocular dryness (OSDI and MDEQ). Our study demonstrates that HNC patients treated with IMRT experience late effects in terms of xerostomia and ocular dryness underlining the importance of interdisciplinary approach in the evaluation and follow-up of HNC patients.
Databáze: MEDLINE
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