| Autor: |
Cheng Y; Department of Chemistry & Biological Engineering, Beijing Key Laboratory for Bioengineering and Sensing Technology, Daxing Research Institute, University of Science & Technology Beijing, Beijing 100083, China. wyq_wen@iccas.ac.cn., Jiao X, Wang Z, Jacobson O, Aronova MA, Ma Y, He L, Liu Y, Tang W, Deng L, Zou J, Yang Z, Zhang M, Wen Y, Fan W, Chen X |
| Jazyk: |
angličtina |
| Zdroj: |
Biomaterials science [Biomater Sci] 2021 Apr 07; Vol. 9 (7), pp. 2584-2597. Date of Electronic Publication: 2021 Feb 17. |
| DOI: |
10.1039/d1bm00015b |
| Abstrakt: |
It is widely accepted that a small particle size and rough surface can enhance tumor tissue accumulation and tumor cellular uptake of nanoparticles, respectively. Herein, sub-50 nm urchin-inspired disulfide bond-bridged mesoporous organosilica nanoparticles (UMONs) featured with a spiky surface and glutathione (GSH)-responsive biodegradability were successfully synthesized by a facile one-pot biphasic synthesis strategy for enhanced cellular internalization and tumor accumulation. l-Arginine (LA) is encapsulated into the mesopores of UMONs, whose outer surface is capped with the gatekeeper of ultrasmall gold nanoparticles, i.e., UMONs-LA-Au. On the one hand, the mild acidity-activated uncapping of ultrasmall gold can realize a tumor microenvironment (TME)-responsive release of LA. On the other hand, the unique natural glucose oxidase (GOx)-mimicking catalytic activity of ultrasmall gold can catalyze the decomposition of intratumoral glucose to produce acidic hydrogen peroxide (H 2 O 2 ) and gluconic acid. Remarkably, these products can not only further facilitate the release of LA, but also catalyze the LA-H 2 O 2 reaction for an increased nitric oxide (NO) yield, which realizes synergistic catalysis-enhanced NO gas therapy for tumor eradication. The judiciously fabricated UMONs-LA-Au present a paradigm of TME-responsive nanoplatforms for both enhanced cellular uptake and tumor-specific precision cascaded therapy, which broadens the range of practical biomedical applications and holds a significant promise for the clinical translation of silica-based nanotheranostics. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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