Embossed topographic depolarisation maps of biological tissues with different morphological structures.

Autor: Ushenko VA; Chernivtsi National University, 2 Kotsiubynskyi Str., Chernivtsi, 58012, Ukraine., Hogan BT; OPEM, ITEE, University of Oulu, 90014, Oulu, Finland., Dubolazov A; Chernivtsi National University, 2 Kotsiubynskyi Str., Chernivtsi, 58012, Ukraine., Grechina AV; Institute of Clinical Medicine N.V. Sklifosovsky, I.M. Sechenov First Moscow State Medical University, Moscow, 129090, Russia., Boronikhina TV; Institute of Clinical Medicine N.V. Sklifosovsky, I.M. Sechenov First Moscow State Medical University, Moscow, 129090, Russia., Gorsky M; Chernivtsi National University, 2 Kotsiubynskyi Str., Chernivtsi, 58012, Ukraine., Ushenko AG; Chernivtsi National University, 2 Kotsiubynskyi Str., Chernivtsi, 58012, Ukraine., Ushenko YO; Chernivtsi National University, 2 Kotsiubynskyi Str., Chernivtsi, 58012, Ukraine., Bykov A; OPEM, ITEE, University of Oulu, 90014, Oulu, Finland., Meglinski I; OPEM, ITEE, University of Oulu, 90014, Oulu, Finland. i.meglinski@aston.ac.uk.; Institute of Clinical Medicine N.V. Sklifosovsky, I.M. Sechenov First Moscow State Medical University, Moscow, 129090, Russia. i.meglinski@aston.ac.uk.; Bukovinian State Medical University, 3 Theatral Sq., Chernivtsi, 58000, Ukraine. i.meglinski@aston.ac.uk.; College of Engineering and Physical Science, Aston University, Birmingham, B4 7ET, UK. i.meglinski@aston.ac.uk.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Feb 16; Vol. 11 (1), pp. 3871. Date of Electronic Publication: 2021 Feb 16.
DOI: 10.1038/s41598-021-83017-2
Abstrakt: Layered topographic maps of the depolarisation due to diffuse biological tissues are produced using a polarisation-holographic Mueller matrix method approach. Histological sections of myocardial tissue with a spatially structured optically anisotropic fibrillar network, and parenchymal liver tissue with a polycrystalline island structure are successfully mapped. The topography of the myocardium maps relates to the scattering multiplicity within the volume and the specific morphological structures of the biological crystallite networks. The overall depolarisation map is a convolution of the effects of these two factors. Parenchymal liver tissues behave broadly similarly, but the different biological structures present cause the degree of scattering multiplicity to increase more rapidly with increasing phase. Through statistical analysis, the dependences of the magnitudes of the first to fourth order statistical moments are determined. These moments characterise the changing distributions of the depolarisation values through the volume of biological tissues with different morphological structures. Parenchymal liver tissue depolarisation maps are characterised by larger mean and variance, and less skewness and kurtosis, compared to the distributions for the myocardium. This work demonstrates that a polarisation-holographic Mueller matrix method can be applied to the assessment of the 3D morphology of biological tissues, with applications in disease diagnosis.
Databáze: MEDLINE
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