Whole blood serotonin levels in healthy elderly are negatively associated with the functional activity of emotion-related brain regions.

Autor: Deza-Araujo YI; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland; Laboratory for Behavioral Neurology and Imaging of Cognition, Department of Neuroscience, Medical School, University of Geneva, Geneva, Switzerland. Electronic address: yacila.dezaaraujo@unige.ch., Baez-Lugo S; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland; Laboratory for Behavioral Neurology and Imaging of Cognition, Department of Neuroscience, Medical School, University of Geneva, Geneva, Switzerland., Vuilleumier P; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland; Laboratory for Behavioral Neurology and Imaging of Cognition, Department of Neuroscience, Medical School, University of Geneva, Geneva, Switzerland., Chocat A; Inserm, UMR-S U1237, Université De Caen-Normandie, GIP Cyceron, Caen, France., Chételat G; Inserm, UMR-S U1237, Université De Caen-Normandie, GIP Cyceron, Caen, France., Poisnel G; Inserm, UMR-S U1237, Université De Caen-Normandie, GIP Cyceron, Caen, France., Klimecki OM; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland; Clinical Psychology and Behavioral Neuroscience, Faculty of Psychology, Technische Universität Dresden, 01187, Dresden, Germany.
Jazyk: angličtina
Zdroj: Biological psychology [Biol Psychol] 2021 Mar; Vol. 160, pp. 108051. Date of Electronic Publication: 2021 Feb 13.
DOI: 10.1016/j.biopsycho.2021.108051
Abstrakt: Understanding the role of neuromodulators of socio-affective processing is important to ensure psychological wellbeing during older years. Here, we investigated the link between blood serotonin levels and brain and behavioral responses to emotional information in healthy elderly. A priori regions of interest (ROI) were selected due to their role in emotion processing and their dense serotonergic innervation. Correlation analyses were performed between ROI-specific responses to emotional stimuli and whole blood serotonin levels. We found significant negative associations between serotonin and functional activity for the bilateral insula, dorsal anterior cingulate cortex and subgenual gyrus. No association with behavioral measures survived correction for multiple testing. Our results mirror prior pharmacological and genetic work on the link between serotonin and emotional brain reactivity in younger adults. Given the involvement of serotonin in several age-related changes, our study encourages future research to characterize the role of this neuromodulator in emotion processing across the lifespan.
(Copyright © 2021 University of Geneva. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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