Serum G protein-coupled estrogen receptor-1 levels and its relation with death in patients with sepsis: a prospective study.

Autor:	Findikli HA; Department of Internal Medicine, Kahramanmaraş Necip Fazil City Hospital, Kahramanmaraş, Turkey - dr-avni@hotmail.com., Erdoğan M; Department of Intensive Care Unit and Internal Diseases, Adana City Training And Research Hospital, Adana, Turkey.
Jazyk:	angličtina
Zdroj:	Minerva anestesiologica [Minerva Anestesiol] 2021 May; Vol. 87 (5), pp. 549-555. Date of Electronic Publication: 2021 Feb 16.
DOI:	10.23736/S0375-9393.20.14855-7
Abstrakt:	Background: The sex hormone estrogen has an immune-supporting role in both trauma and sepsis-related to its immune-modulator role. The aim of the current study was to examine the prognostic role of (serum G Protein-coupled estrogen receptor-1) GPER-1 in sepsis and sepsis-related mortality. Methods: Prospective evaluation was made of the data on a total 160 patients followed-up in the Intensive Care Unit because of sepsis. Patients were separated into two groups as survivor and non-survivor group. The Sequential Organ Failure Assessment (SOFA) Score, APACHE II Score and Charlson Comorbidity Index (CCI) were calculated for each patient. Serum GPER-1 levels were evaluated for each patient. Results: Compared with non-survivors, the surviving patients were determined with significantly higher levels of PLT, CRP, GPER-1, SOFA, and APACHE II scores. The GPER-1 levels showed a significant positive correlation with CRP levels, SOFA, and APACHE II scores. ROC curve analysis demonstrated 85.7% sensitivity and 72.1% specificity of GPER-1 to predict 28-day mortality. GPER-1 and APACHE II scores were determined to be an independent prognostic factor for predicting mortality. Conclusions: Serum GPER-1 can be used as a new prognostic factor for survival in patients diagnosed with sepsis.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu