High Rates of SARS-CoV-2 Family Transmission in Children of Healthcare Workers During the First Pandemic Wave in Madrid, Spain: Serologic Study.

Autor:	Méndez-Echevarría A; From the Pediatrics and Infectious Disease Unit, Hospital Universitario La Paz, Fundación IdiPaz.; Translational Research Network of Pediatric Infectious Diseases (RITIP), Madrid., Sainz T; From the Pediatrics and Infectious Disease Unit, Hospital Universitario La Paz, Fundación IdiPaz.; Translational Research Network of Pediatric Infectious Diseases (RITIP), Madrid., de Felipe B; Translational Research Network of Pediatric Infectious Diseases (RITIP), Madrid.; Pediatrics, Infectious Diseases, Rheumatology and Immunology Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain., Alcolea S; From the Pediatrics and Infectious Disease Unit, Hospital Universitario La Paz, Fundación IdiPaz.; Translational Research Network of Pediatric Infectious Diseases (RITIP), Madrid., Olbrich P; Translational Research Network of Pediatric Infectious Diseases (RITIP), Madrid.; Pediatrics, Infectious Diseases, Rheumatology and Immunology Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain., Goycochea-Valdivia WA; Translational Research Network of Pediatric Infectious Diseases (RITIP), Madrid.; Pediatrics, Infectious Diseases, Rheumatology and Immunology Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain., Escosa-García L; From the Pediatrics and Infectious Disease Unit, Hospital Universitario La Paz, Fundación IdiPaz.; Translational Research Network of Pediatric Infectious Diseases (RITIP), Madrid., Cobo L; From the Pediatrics and Infectious Disease Unit, Hospital Universitario La Paz, Fundación IdiPaz., Calvo C; From the Pediatrics and Infectious Disease Unit, Hospital Universitario La Paz, Fundación IdiPaz.; Translational Research Network of Pediatric Infectious Diseases (RITIP), Madrid., Neth O; Translational Research Network of Pediatric Infectious Diseases (RITIP), Madrid.; Pediatrics, Infectious Diseases, Rheumatology and Immunology Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
Jazyk:	angličtina
Zdroj:	The Pediatric infectious disease journal [Pediatr Infect Dis J] 2021 May 01; Vol. 40 (5), pp. e185-e188.
DOI:	10.1097/INF.0000000000003088
Abstrakt:	Background: Data on SARS-CoV-2 transmission among children living with healthcare workers (HCWs) are scarce. Methods: A cross-sectional study was performed at a tertiary Hospital in Madrid, including children of HCW who suffered from SARS-CoV-2 infection between March and May 2020. Children underwent enzyme-linked immunosorbent serological study for detecting SARS-CoV-2 antibodies: VIRCELL IgG assay. Results: One hundred thirteen children from 69 HCWs with confirmed SARS-CoV-2 infection were recruited: 47 children had positive IgG (41.6%). Children secondary attack rate was 43.7% (25% if both parents have had asymptomatic infection; 39.5% if one parent was symptomatic; and 47% when both parents had symptoms). Having a positive sibling was associated with a positive IgG result (odds ratio = 12.2; 95% confidence interval: 4.4-33.7, P < 0.001). Median age was higher in IgG positive children (P = 0.022). Children who referred anosmia presented higher IgG titles (P < 0.04). Conclusions: We observed a very high SARS-CoV-2 transmission in children of HCW during the first pandemic wave, especially when both parents were symptomatic. Having a positive sibling was associated with seroconversion, supporting the important role of family clusters in the transmission of SARS-CoV-2. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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