Trace element profile and incidence of type 2 diabetes, cardiovascular disease and colorectal cancer: results from the EPIC-Potsdam cohort study.

Autor: Cabral M; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, 14558, Nuthetal, Germany. maria.cabral@dife.de.; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin-Jena, Germany. maria.cabral@dife.de., Kuxhaus O; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, 14558, Nuthetal, Germany., Eichelmann F; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, 14558, Nuthetal, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany., Kopp JF; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin-Jena, Germany.; Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, 14558, Nuthetal, Germany., Alker W; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin-Jena, Germany.; Department of Food Chemistry and Toxicology, Institute of Food Technology and Food Chemistry, Technische Universität Berlin, 13355, Berlin, Germany., Hackler J; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin-Jena, Germany.; Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, CVK, Augustenburger Platz 1, 13353, Berlin, Germany., Kipp AP; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin-Jena, Germany.; Department of Molecular Nutritional Physiology, Institute of Nutritional Sciences, Friedrich Schiller University Jena, 07743, Jena, Germany., Schwerdtle T; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin-Jena, Germany.; Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, 14558, Nuthetal, Germany., Haase H; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin-Jena, Germany.; Department of Food Chemistry and Toxicology, Institute of Food Technology and Food Chemistry, Technische Universität Berlin, 13355, Berlin, Germany., Schomburg L; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin-Jena, Germany.; Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, CVK, Augustenburger Platz 1, 13353, Berlin, Germany., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, 14558, Nuthetal, Germany.; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin-Jena, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, 14558, Nuthetal, Germany.; Institute of Nutritional Science, University of Potsdam, 14558, Nuthetal, Germany.
Jazyk: angličtina
Zdroj: European journal of nutrition [Eur J Nutr] 2021 Sep; Vol. 60 (6), pp. 3267-3278. Date of Electronic Publication: 2021 Feb 15.
DOI: 10.1007/s00394-021-02494-3
Abstrakt: Purpose: We aimed to examine the prospective association between manganese, iron, copper, zinc, iodine, selenium, selenoprotein P, free zinc, and their interplay, with incident type 2 diabetes (T2D), cardiovascular disease (CVD) and colorectal cancer (CRC).
Methods: Serum trace element (TE) concentrations were measured in a case-cohort study embedded within the EPIC-Potsdam cohort, consisting of a random sub-cohort (n = 2500) and incident cases of T2D (n = 705), CVD (n = 414), and CRC (n = 219). TE patterns were investigated using principal component analysis. Cox proportional hazard models were fitted to examine the association between TEs with T2D, CVD and CRC incidence.
Results: Higher manganese, zinc, iodine and selenium were associated with an increased risk of developing T2D (HR Q5 vs Q1: 1.56, 1.09-2.22; HR per SD, 95% CI 1.18, 1.05-1.33; 1.09, 1.01-1.17; 1.19, 1.06-1.34, respectively). Regarding CVD, manganese, copper and copper-to-zinc ratio were associated with an increased risk (HR per SD, 95% CI 1.13, 1.00-1.29; 1.22, 1.02-1.44; 1.18, 1.02-1.37, respectively). The opposite was observed for higher selenium-to-copper ratio (HR Q5 vs Q1, 95% CI 0.60, 0.39-0.93). Higher copper and zinc were associated with increasing risk of developing CRC (HR per SD, 95% CI 1.29, 1.05-1.59 and 1.14, 1.00-1.30, respectively). Selenium, selenoprotein P and selenium-to-copper-ratio were associated to decreased risk (HR per SD, 95% CI 0.82, 0.69-0.98; 0.81, 0.72-0.93; 0.77, 0.65-0.92, respectively). Two TE patterns were identified: manganese-iron-zinc and copper-iodine-selenium.
Conclusion: Different TEs were associated with the risk of developing T2D, CVD and CRC. The contrasting associations found for selenium with T2D and CRC point towards differential disease-related pathways.
(© 2021. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje