| Autor: |
Miranda MA; Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri., Macias-Velasco JF; Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri., Lawson HA; Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri. |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2021 Apr 01; Vol. 320 (4), pp. E716-E731. Date of Electronic Publication: 2021 Feb 15. |
| DOI: |
10.1152/ajpendo.00649.2020 |
| Abstrakt: |
Pancreatic β-cells perform glucose-stimulated insulin secretion, a process at the center of type 2 diabetes etiology. Efforts to understand how β-cells behave in healthy and stressful conditions have revealed a wide degree of morphological, functional, and transcriptional heterogeneity. Sources of heterogeneity include β-cell topography, developmental origin, maturation state, and stress response. Advances in sequencing and imaging technologies have led to the identification of β-cell subtypes, which play distinct roles in the islet niche. This review examines β-cell heterogeneity from morphological, functional, and transcriptional perspectives, and considers the relevance of topography, maturation, development, and stress response. It also discusses how these factors have been used to identify β-cell subtypes, and how heterogeneity is impacted by diabetes. We examine open questions in the field and discuss recent technological innovations that could advance understanding of β-cell heterogeneity in health and disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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