Synthesis and in vitro study of antiproliferative benzyloxy dihydropyrimidinones.
| Autor: | Vala RM; Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India., Sharma MG; Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India., Patel DM; Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India., Puerta A; BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, La Laguna, Spain., Padrón JM; BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, La Laguna, Spain., Ramkumar V; Department of Chemistry, Indian Institute of Technology-Madras, Chennai, Tamil Nadu, India., Gardas RL; Department of Chemistry, Indian Institute of Technology-Madras, Chennai, Tamil Nadu, India., Patel HM; Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India. |
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| Jazyk: | angličtina |
| Zdroj: | Archiv der Pharmazie [Arch Pharm (Weinheim)] 2021 Jun; Vol. 354 (6), pp. e2000466. Date of Electronic Publication: 2021 Feb 15. |
| DOI: | 10.1002/ardp.202000466 |
| Abstrakt: | In this study, we report on antiproliferative benzyloxy dihydropyrimidinones (DHPMs) produced by the Biginelli reaction of benzyloxy benzaldehyde, urea, and diverse 1,3-diones. The reaction was catalyzed by lanthanum triflate and completed within 1-1.5 h, with 74-97% yield. The antiproliferative assay was carried out for all synthesized dihydropyrimidinones against six human solid tumor cell lines. Six compounds showed good antiproliferative activity with GI (© 2021 Deutsche Pharmazeutische Gesellschaft.) |
| Databáze: | MEDLINE |
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