| Autor: |
Kramer JW; College of Veterinary Medicine, Washington State University, Pullman 99164., Klaassen JK, Baskin DG, Prieur DJ, Rantanen NW, Robinette JD, Graber WR, Rashti L |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of veterinary research [Am J Vet Res] 1988 Mar; Vol. 49 (3), pp. 428-31. |
| Abstrakt: |
The genetic aspects of inherited, insulin-dependent diabetes mellitus of Keeshond dogs were studied retrospectively and in a prospective mating program. The symbol dm was used to designate the gene that causes hypoplasia of the islets of Langerhans. The retrospective study disclosed 4 diabetic dogs; prospective outcross, backcross, and inbred matings disclosed 49 diabetic dogs. Outcrossing demonstrated that the diabetic phenotype was displayed readily against a genetic background of a breed other than the Keeshond. In dogs with the dm/dm genotype, onset of diabetes was most frequent before the dog was 6 months old, but did occur in some older dogs. The dm genotype was best described as autosomal recessive. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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