Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease.

Autor:	Palmer WC; Department of Radiology, University of Washington Medical Center, Seattle, WA, United States., Cholerton BA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States., Zabetian CP; Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States.; Department of Neurology, University of Washington School of Medicine, Seattle, WA, United States., Montine TJ; Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States., Grabowski TJ; Department of Radiology, University of Washington Medical Center, Seattle, WA, United States.; Department of Neurology, University of Washington School of Medicine, Seattle, WA, United States., Rane S; Department of Radiology, University of Washington Medical Center, Seattle, WA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in neurology [Front Neurol] 2021 Jan 28; Vol. 11, pp. 594213. Date of Electronic Publication: 2021 Jan 28 (Print Publication: 2020).
DOI:	10.3389/fneur.2020.594213
Abstrakt:	Purpose: Recently, the cerebellum's role in Parkinson's disease (PD) has been highlighted. Therefore, this study sought to test the hypothesis that functional connectivity (FC) between cerebellar and cortical nodes of the resting-state networks differentiates PD patients from controls by scanning participants at rest using functional magnetic resonance imaging (fMRI) and investigating connectivity of the cerebellar nodes of the resting-state networks. Materials and Methods: Sixty-two PD participants off medication for at least 12 h and 33 normal controls (NCs) were scanned at rest using blood oxygenation level-dependent fMRI scans. Motor and cognitive functions were assessed with the Movement Disorder Society's Revision of the Unified Parkinson's Disease Rating Scale III and Montreal Cognitive Assessment, respectively. Connectivity was investigated with cerebellar seeds defined by Buckner's 7-network atlas. Results: PD participants had significant differences in FC when compared to NC participants. Most notably, PD patients had higher FC between cerebellar nodes of the somatomotor network (SMN) and the corresponding cortical nodes. Cognitive functioning was differentially associated with connectivity of the cerebellar SMN and dorsal attention network. Further, cerebellar connectivity of frontoparietal and default mode networks correlated with the severity of motor function. Conclusion: Our study demonstrates altered cerebello-cortical FC in PD, as well as an association of this FC with PD-related motor and cognitive disruptions, thus providing additional evidence for the cerebellum's role in PD. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Palmer, Cholerton, Zabetian, Montine, Grabowski and Rane.)
Databáze:	MEDLINE
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