Association of AdipoQ gene variation (rs1501299) and oxidative stress with cardiovascular disease in North West Indian population of Punjabi women.
| Autor: | Amrita J; Sri Guru Ram Das Institute of Medical Sciences and Research, Department of Biochemistry, Amritsar, Punjab, India., Mahajan M; Government Medical College, Department of Biochemistry, Amritsar, Punjab, India., Bhanwer AJS; Guru Nanak Dev University, Department of Human Genetics, Amritsar, Punjab, India., Matharoo K; Guru Nanak Dev University, Department of Human Genetics, Amritsar, Punjab, India. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of medical biochemistry [J Med Biochem] 2021 Jan 26; Vol. 40 (1), pp. 49-59. |
| DOI: | 10.5937/jomb0-24704 |
| Abstrakt: | Background: Till to date whether adiponectin AdipoQ gene variation (rs 1501299) is associated with cardiovascular disease, still remains controversial. Therefore, we aimed to relate the SNP (rs1501299) of adiponectin gene and oxidative stress in context to CVD in Punjabi women of North West India. Methods: In the present case-control study menopausal women with CVD as cases (n=265) and menopausal women without CVD as controls (n=258) were recruited. Genotyping of rs1501299 single nucleotide polymorphism of adiponectin gene was carried out by RFLP-PCR analysis. Biochemical parameters were analyzed according to the standard procedures. Results: Distribution of homozygous TT genotype of normolipidemic (p=0.001) and hyperlipidemic (p=0.001) women with CVD was significantly more frequent as compared to women without CVD. rs1501299 T allele carriers with CVD also showed significant (p=0.001) higher frequency distribution as compared to women without CVD. Under recessive model of inheritance TT mutant type homozygotes conferred ~9 fold higher risk [p=0.001; OR= 9.60 (2.92-31.58)] towards CVD susceptibility for MDA>1.50; ~11 fold higher risk [p=0.007; OR= 11.11 (1.49-82.83)] towards CVD for LDL carbonyl protein>15.04 and ~9 fold higher risk [p=0.001; OR= 9.75 (2.30-41.22)] towards CVD susceptibility for SOD≤5.55. Under logistic regression analysis oxidative stress and TT genotype were significantly correlated with CVD. Conclusions: Our study revealed significant association of AdipoQ (rs1501299) gene polymorphism and oxidative stress with cardiovascular disease in Punjabi women of North West India. However, additional studies are required to support these findings. Competing Interests: Conflict of Interest: The authors stated that they have no conflicts of interest regarding the publication of this article. (2021 Jyot Amrita, Mridula Mahajan, A.J.S. Bhanwer, Kawaljit Matharoo, published by CEON/CEES.) |
| Databáze: | MEDLINE |
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