Advances in the Diagnosis and Management of Neonatal Sarcomas.

Autor:	Rashid T; Pediatric Hematology/Oncology, Duke University School of Medicine, DUMC, Box 102382, Durham, NC 27710, USA., Noyd DH; Pediatric Hematology/Oncology, Duke University School of Medicine, DUMC, Box 102382, Durham, NC 27710, USA., Iranzad N; Pediatric Hematology/Oncology, Duke University School of Medicine, DUMC, Box 3712, Durham, NC 27710, USA., Davis JT; Pediatric Hematology/Oncology, Duke University School of Medicine, DUMC, Box 3808, Durham, NC 27710, USA., Deel MD; Pediatric Hematology/Oncology, Duke University School of Medicine, DUMC, Box 102382, Durham, NC 27710, USA. Electronic address: michael.deel@duke.edu.
Jazyk:	angličtina
Zdroj:	Clinics in perinatology [Clin Perinatol] 2021 Mar; Vol. 48 (1), pp. 117-145.
DOI:	10.1016/j.clp.2020.11.007
Abstrakt:	Neonatal sarcomas comprise a heterogeneous group of rare soft tissue neoplasms that present unique diagnostic and therapeutic challenges. Recent advances in molecular profiling have improved diagnostic capabilities and reveal novel therapeutic targets. Clinical trials demonstrate differences in behavior between sarcoma subtypes that allow for better clinical management. Surgical resection has been replaced with a multimodal approach that includes chemotherapy and radiotherapy. Despite these advances, neonates with sarcoma continue to fare worse than histologically similar sarcomas in older children, likely reflecting differences in tumor biology and the complexities of neonatal medicine. This review focuses on recent advances in managing neonatal sarcomas. Competing Interests: Disclosures The authors have no commercial or financial conflicts of interest to declare. This work was supported by a V Foundation Scholar Award (M.D. Deel). (Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu